The Association Between Anemia and Cardiomegaly

Anemia is one of the major global problems that continues to this day. According to World Health Organization (WHO) data, anemia is found in 1.62 billion people or equivalent to 24.8% of the world's population while, the prevalence of anemia in children under 6 years of age in Indonesia reached 38.4%. Anemia, if undiagnosed or untreated for a long period of time can lead to multiorgan failure. The cardiovascular system is the most commonly affected system in chronic anemia. Between one-third and two-thirds of patients with severe anemia have cardiomegaly and this will return to normal within a few weeks after the anemia is well managed. This abnormality can be evaluated on chest radiograph or echocardiography.

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Key information

Conditions

Anemia in Children Cardiomegaly Cardiovascular Diseases Heart Diseases Hypertrophy Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms

Age range

1 day–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Universitas Sumatera Utara

Medan, North Sumatera, 20155, Indonesia

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Anemia patients aging maximum 18 years old
Anemia patients who had undergone chest radiograph and echocardiography

Exclusion criteria

Anemia patients who had undergone definitive surgery
Anemia patients who had took iron supplementation in the last 3 months
Anemia patients who had other anemic conditions such as chronic kidney disease or hemolytic anemia

Treatment and study plan

Primary outcomes

Anemia

Time frame: April 2023 - September 2023

Diagnosis of anemia based on Hb levels according to WHO classification
Cardiomegaly

Time frame: April 2023 - September 2023

Diagnosis of cardiomegaly based on chest radiograph and echocardiography

Sponsors and collaborators

Lead sponsor

Universitas Sumatera Utara

Other

Registry information

Official study title

The Association Between Anemia (Hemoglobin Level) and Cardiomegaly Based On Chest Radiograph and Echocardiography

Important dates

Study start: 2023
Primary completion: 2023
Study completion: 2023
First posted: Apr 18, 2023
Registry last updated: Mar 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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