The ARISE Study - Use of Vertical Positioning

The pilot study will randomize 40 ARDS patients who if proning were required would be randomized to upright bed positioning or to stand of care with bed in the head of bed elevation position

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Key information

Conditions

Acute Respiratory Distress Syndrome Lung Diseases Respiration Disorders Respiratory Distress Syndrome Respiratory Tract Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Alabama at Birmingham

Birmingham, Alabama, 35223, United States

Location status: Recruiting

About this study

Patients will be randomized to receive either daily upright bed positioning or to receive standard of care with head of bed elevated.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Acute Respiratory Distress Syndrome

Exclusion criteria

Cancer
Active tracheostomy

Treatment and study plan

Intervention Upright Bed positioning

Other

Patient in receipt of the upright bed positioning will receive daily upright bed positioning time each day of mechanical ventilation following the time required by institutional protocol for ARDS - associated prone positioning

Primary outcomes

Change in Tidal Volume

Time frame: within first 7 days of mechanical ventilation

Mechanical Ventilator Tidal Volume

Study contacts

Contact information is provided by the study sponsor or research team.

peter morris, md

CONTACT

[email protected]

205-934-5548

Sponsors and collaborators

Lead sponsor

University of Alabama at Birmingham

Other

Registry information

Acronym: ARISE

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Jun 17, 2025
Registry last updated: Sep 2, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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