The Application of Extracellular Vesicle Detection in Gastric Juice Based on Metamaterial Sensing in the Diagnosis of Gastric Cancer and Related Diseases

After obtaining informed consent from the patients, all the medical history and treatment records of the patients who underwent gastroscopy since the onset of the disease, as well as gastric fluid samples, including laboratory and imaging data, were collected and recorded. The medical history and treatment records and gastric fluid samples were analyzed.

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Key information

Conditions

Gastric Cancer (GC) Digestive System Diseases Digestive System Neoplasms Disease Gastric Cancer (Diagnosis) Gastrointestinal Diseases Gastrointestinal Neoplasms Neoplasms Neoplasms by Site Pathologic Processes Pathological Conditions, Signs and Symptoms Stomach Diseases Stomach Neoplasms

Age range

40 year–70 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients underwent gastroscopy and treatment at the Endoscopy Center of Beijing Friendship Hospital, Capital Medical University, and received pathological biopsy.
Previous gastroscopy suggested the possibility of lesions.
No previous history of gastrointestinal cancer.

Exclusion criteria

Patients could not cooperate with the examination or had contraindications to endoscopy.
Previous history of gastrointestinal tumors, gastrointestinal surgery, physical and chemical injuries of the gastrointestinal tract.
Severe bile reflux.
Take simethicone and other defoaming agents before examination.
Patients with serious diseases of heart, lung, kidney, brain, blood and other important organs.

Treatment and study plan

In vitro surface plasmon resonance detection

Diagnostic Test

Gastric juice from patients was removed for isolation of extracellular vesicles and surface plasmon resonance detection in vitro

Primary outcomes

Surface plasmon resonance(SPR) detection of extracellular vesicles in gastric juice of patients with gastric cancer has large shift and spectral changes

Time frame: baseline

Study contacts

Contact information is provided by the study sponsor or research team.

Hao-Su Zhan, Dr.

CONTACT

[email protected]

13565915192

Sponsors and collaborators

Lead sponsor

Beijing Friendship Hospital

Other

Registry information

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Jan 12, 2026
Registry last updated: Jan 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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