The Antipyretic Efficacy of Oral and Intravenous Paracetamol and Intramuscular Diclofenac in Patients Presenting With Fever.

A randomized clinical trial to check the antipyretic efficacy of oral and intravenous paracetamol and intramuscular diclofenac sodium in patients presenting with fever to emergency department.

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Key information

Conditions

Fever Body Temperature Changes Disease Attributes Emergencies Pathologic Processes Pathological Conditions, Signs and Symptoms Reduction in Temperature Signs and Symptoms

Age range

14 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hamad medical corporation

Doha, 3050, Qatar

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adults between the age of 14-75 years with an oral temperature of more than 38.5 C

Exclusion criteria

History of allergy to any of the drugs in the study
Had taken antipyretics within 8 hours
Renal, hepatic or haematological disorders
bronchial asthma, peptic ulcer disease, vomiting
Pregnant or lactating women

Treatment and study plan

Oral paracetamol

Drug

after giving medicine temperature is checked every 30 minutes for 2 hours

Intravenous paracetamol

Drug

after giving medicine temperature is checked every 30 minutes for 2 hours

Intramuscular diclofenac

Drug

after giving medicine temperature is checked every 30 minutes for 2 hours

Primary outcomes

Reduction in temperature in every thirty minutes till 120 minutes after receiving antipyretics

Time frame: Reduction in temperature is checked every 30 minutes for a maximum of 120 minutes

Once the patients fulfill the inclusion criteria, they are randomly assigned to receive one of the three medications in the study ( oral paracetamol, intravenous paracetamol or intramuscular diclofenac). Baseline temperature is recorded using a standard thermometer. Then reduction in temperature is recorded every 30 minutes for 2 hours.

Sponsors and collaborators

Lead sponsor

Hamad Medical Corporation

Industry

Registry information

Official study title

A Randomized Controlled Clinical Trial on the Antipyretic Efficacy of Oral Paracetamol, Intravenous Paracetamol and Intramuscular Diclofenac in Patients Presenting With Fever to Emergency Department

Important dates

Study start: 2010
Primary completion: 2011
Study completion: 2013
First posted: Jul 3, 2013
Registry last updated: Jul 3, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed