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NCT Number: NCT04136639

The Anticariogenic Effect of Miswak (Silvadora Persica) and Grape Seed Extract

Prevention of dental caries has taken a great importance in the last decade. The use of herbal and natural products became mandatory to avoid the side effects of commercially available medications. Aim of the study; the aim was to investigate the anti-cariogenic effect of miswak and grape seed extract (GSE).

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Key information

Conditions

Dental Caries Stomatognathic Diseases Tooth Demineralization Tooth Diseases

Age range

20 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Al Azhar University

Cairo, Nasr City, Egypt

About this study

Patients used Miswak sticks, grape seed extract mouth wash and fluoride mouthwash twice daily for three month. Saliva samples were collected at base line and after one month and three month. Assessment of bacterial count and saliva buffering capacity were performed at base line and after one and three month.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with high caries risk
  • Males or females
  • Medically free patients
  • Patients approving to participate in the study

Exclusion criteria

  • Patients who were on antibiotic therapy or corticosteroid therapy for 30 days before the examination
  • Patients had history of professional cleaning in the last 15 days
  • Patients with exposed pulp
  • Evidence of parafunctional habits
  • Patients with developmental dental anomalies
  • Patients undergoing or will start orthodontic treatment
  • Patients with removable prosthesis
  • Periapical Abscess or Fistula

Treatment and study plan

Miswak

Other

sticks

Other names: silvadora persica

Grape Seed Extract Mouthwash

Other

Mouthwash

Other names: 95% proanthocyanidins

Fluoride

Other

mouthwash

Other names: 0.05% sodium fluoride

Primary outcomes

  1. quantitative measure of the change in salivary streptococcus mutans Count from baseline to one month and three months.

    Time frame: Baseline, one month, three months.

    the patients used the treatments twice daily for three months. unstimulated saliva samples were collected from the patients at baseline,after one month and after three months. Every time samples were incubated with Mitiis Salivaris with Bacitricin and 20% sucrose for streptococcus mutans count.

Secondary outcomes

  1. quantitative measure of the change in saliva buffering capacity from baseline to one month and three months.

    Time frame: baseline, one month , three months

    the patients used the treatments twice daily for three months. unstimulated saliva samples were collected from the patients at baseline, after one month and after three months. each time, saliva buffering capacity was measured using Hand Held pH meter and 0.1 mol/l hydrochloric acid that was titrated to the tested saliva.

Sponsors and collaborators

Lead sponsor

Al-Azhar University

Other

Registry information

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Oct 23, 2019
Registry last updated
Oct 23, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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