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OpenTrials
Completed

NCT Number: NCT00468507

The Anti-inflammatory Effects of High-fat Nutrition; Towards a Clinical Application

Patients undergoing major surgery, trauma and burns are prone to develop an exacerbated inflammatory response, which is potentially lethal to the individual. Recently our group demonstrated that administration of high fat feeding prior to hemorrhagic shock attenuates severe inflammation, gut barrier loss and hepatic damage. High fat feeding releases cholecystokinin in the gut, which stimulates the autonomous nervous system and subsequently activates the efferent vagus nerve. The activated efferent fibers inhibit tissue macrophages via binding of acetylcholine to the alpha7-nicotinergic receptor.

In this study the cholecystokinin release in healthy volunteers is monitored in response to low fat and high fat food products.

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Key information

Conditions

Trauma Wounds and Injuries

Age range

45 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

University Maastricht

Maastricht, Limburg, 6200 MD, Netherlands

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy males and females
  • 45 > age <55

Exclusion criteria

  • Gastrointestinal diseases
  • Inflammatory conditions

Treatment and study plan

nutritional intervention with Respifor and Diasip

Dietary Supplement

Four nutritional interventions on four separate days per test person

Primary outcomes

  1. CCK-release

    Time frame: two hours

Sponsors and collaborators

Lead sponsor

Maastricht University Medical Center

Other

Registry information

Important dates

Study start
2007
Primary completion
2010
Study completion
2010
First posted
May 2, 2007
Registry last updated
Mar 31, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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