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OpenTrials
Completed

NCT Number: NCT05925244

The Anabolic and Catabolic Effect of Loaded and Unloaded Exercise on Articular Cartilage Health

The serum concentration of cartilage oligomeric matrix protein (sCOMP) has been considered a mechano-sensitive biomarker of articular cartilage turnover, and N-propeptide of type II collagen (PIIANP) is a proposed biomarker of type II collagen synthesis. Few studies have investigated both the anabolic and turnover response of articular cartilage as a result of acute changes in body weight mass during exercise. Using a repeated measures cross-over design, fifteen healthy adults (age 18-30 years) performed three, 30-minute bouts of treadmill walking exercise under 3 loading conditions: (1) control (no alteration to body mass); (2) loaded (12% increase in body mass using a weighted vest); and (3) unloaded (12% decrease in body mass using lower body positive pressure). Venous blood was collected before, immediately after, and 15 and 30 minutes after exercise to investigate cartilage turnover (sCOMP) and anabolism (PIIANP).

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Key information

Conditions

Healthy

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Manitoba

Winnipeg, Manitoba, R3T 2N2, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy
  • 18-30 years old

Exclusion criteria

  • Traumatic injury to the lower extremity in the past year
  • Hip, knee, or ankle surgery
  • Radiographic evidence of joint degeneration
  • Cardiovascular disease
  • Ankylosing spondylitis
  • Psoriatic arthritis
  • Chronic reactive arthritis
  • Renal problems requiring peritoneal dialysis or hemodialysis
  • Not currently using any prescription or non-prescription medications and/or nutritional supplements

Treatment and study plan

Control condition

Other

Control (no alteration to body mass).

+12% Body Mass

Other

Loaded walking exercise (12% increase in body mass using a weighted vest).

-12% Body Mass

Other

Unloaded walking exercise (12% decrease in body mass using lower body positive pressure).

Primary outcomes

  1. Serum cartilage oligomeric matrix protein (sCOMP)

    Time frame: sCOMP was measured at baseline, immediately post, and 15- and 30-minutes post exercise.

    The systemic blood serum concentration of sCOMP was evaluated in all participants under the 3 conditions in a crossover trial.

  2. N-propeptide of type II collagen (PIIANP)

    Time frame: PIIANP was measured at baseline, immediately post, and 15- and 30-minutes post exercise.

    The systemic blood serum concentration of PIIANP was evaluated in all participants under the 3 conditions in a crossover trial.

Sponsors and collaborators

Lead sponsor

University of Manitoba

Other

Registry information

Official study title

A Preliminary Study on the Effect of Loaded and Unloaded Exercise on Anabolic and Turnover Activity of Articular Cartilage in Healthy Young Adults

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Jun 29, 2023
Registry last updated
Jul 3, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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