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NCT Number: NCT06366399

The Acute T-Rex (Timing of Resistance Exercise) Study

The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laboratory setting. Each condition will consist of exercise, overnight sleep, and oral glucose tolerance tests the following day. The AM exercise will occur ~1.5 hours after habitual wake, and PM exercise will occur ~11 hours after habitual wake. After a 2-6 week washout, participants will complete the other condition. The hypothesis is that PM exercise will be more beneficial than AM exercise in improving insulin sensitivity. This study could identify if there is a better time of day to perform resistance exercise to decrease risk of developing Type 2 Diabetes Mellitus.

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Key information

Conditions

Diabetes Mellitus, Type 2 Body Weight Diabetes Mellitus Endocrine System Diseases Glucose Intolerance Glucose Metabolism Disorders Hyperglycemia Hyperinsulinism Insulin Resistance Insulin Sensitivity Mental Disorders Metabolic Diseases Nervous System Diseases Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Overweight or Obesity Parasomnias Pathological Conditions, Signs and Symptoms Signs and Symptoms Sleep Disturbance Sleep Wake Disorders

Age range

50 year–74 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Utah HPER E Buildling

Salt Lake City, Utah, 84112, United States

Location status: Recruiting

Location contact

Jason V Thomas, MS

CONTACT

[email protected]

Tanya M Halliday, PhD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and women, all ethnicities, aged 50-74 years
  • BMI ≥25 kg/m² and <45 kg/m²
  • Weight stable (less than 5% change in the past 6 months)
  • Generally healthy individuals
  • Not meeting recommended activity guidelines for aerobic or resistance exercise

Exclusion criteria

  • Uncontrolled cardiovascular, metabolic, renal, or pulmonary disease
  • Cancer treatment in the past 5 years
  • Untreated thyroid disease or other medical conditions affecting weight or energy metabolism
  • Current use of weight loss medication or other medications likely to impact energy balance
  • Bariatric surgery or extensive bowel resection in the past 2 years
  • Current or recent history (past 2 years) of eating disorder
  • Diagnosis of insomnia, sleep apnea, or other sleep and circadian disorders
  • Non-English speaking
  • HbA1c >6.5%

Treatment and study plan

Resistance Exercise Timing

Behavioral

1 resistance exercise session consisting of 3 sets, 10 repetitions per set, on 12 different exercises

Other names: Exercise, Strength-Training, Weightlifting

Primary outcomes

  1. Insulin sensitivity

    Time frame: 1 day

    Insulin sensitivity will be calculated using the Matsuda Insulin Sensitivity Index

Secondary outcomes

  1. Sleep Duration

    Time frame: 1 day

    Sum of time spent in stage 1, stage 2, stage 3 and rapid eye movement stage (REM) as assessed via polysomnography.

Other outcomes

  1. Sleep Staging

    Time frame: 1 day

    Time spent in stage 1, stage 2, stage 3 and REM sleep assessed by polysomnography.

  2. Sleep Quality

    Time frame: 1 day

    As assessed via Pittsburg Sleep Quality Index Questionnaire (scale:0-21, higher scores=worse outcome) and polysomnography

  3. Sleep Efficiency

    Time frame: 1 day

    Ratio of time in bed vs time asleep

  4. Muscular Strength

    Time frame: 1 day

    Muscular strength as assessed via 10 repetition maximum test

  5. Perceived Hunger

    Time frame: 1 day

    Visual Analog Scales (scale: 0-100)

  6. Perceived Fullness

    Time frame: 1 day

    Visual Analog Scales (scale: 0-100)

  7. Perceived Prospective Food Consumption

    Time frame: 1 day

    Visual Analog Scales (scale: 0-100)

  8. Glucose Area Under Curve

    Time frame: 1 day

    Mathematical calculation using fasting, 10,20,30,60,90,120 min blood glucose

  9. Insulin Area Under Curve

    Time frame: 1 day

    Mathematical calculation using fasting, 10,20,30,60,90,120 min blood insulin

Study contacts

Contact information is provided by the study sponsor or research team.

Study Email Study Email

CONTACT

[email protected]

8014487897

Tanya M Halliday, PhD

CONTACT

[email protected]

801-213-1364

Sponsors and collaborators

Lead sponsor

University of Utah

Other

Registry information

Official study title

Timing (AM v PM) of Acute Resistance Exercise on Glycemic Control in Older Adults: The Acute T-Rex Study

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Apr 15, 2024
Registry last updated
Apr 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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