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Completed

NCT Number: NCT01124487

The Acute Effects of Oleic Acid Enriched-diets on Lipids, Insulin Sensitivity and Serum Inflammatory Markers

Objectives: To investigate the acute effects of olive oil, palm olein and lard on lipid profile, insulin sensitivity and inflammatory markers.

Hypothesis: Different dietary fats will alter lipid profile, insulin sensitivity and inflammatory markers postprandially.

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Key information

Conditions

Lipid Profile Glucose Metabolism Disorders Hyperinsulinism Inflammation Insulin Resistance Metabolic Diseases Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Platelet Glycoprotein IV Deficiency

Age range

18 year–45 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Malaysian Palm Oil Board

Kajang, Selangor, 43000, Malaysia

About this study

A randomized, single blind, crossover design was undertaken to test meals enriched with palm olein vs olive oil vs lard. Volunteers were asked to participate in three postprandial challenges, separated by at least 3-days. Subjects were provided a low fat meal(<10g fat) the day before the intervention. Fasting blood was collected the next day and the subjects were instructed to consume test meals (50g high fat meal). Further venous blood was collected at 30 min, 1h, 2h, 3h and 4h postprandially.

Primary outcome variable: Triacylglycerol (TAG) Secondary outcome variables: Insulin sensitivity (glucose, insulin), non esterified fatty acids (NEFA), inflammatory markers

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age: 18-45 years
  • BMI : 18.5-30 kg/m^2
  • Healthy, men

Exclusion criteria

  • medical history of cardiovascular disease, cancer, diabetes or chronic diseases
  • BMI < 18.5 OR > 30 kg/m^2
  • waist hip ratio > 0.9
  • total cholesterol > 5.2 mmol/L
  • triacylglycerol (TAG) > 2.2 mmol/L
  • current use of antihypertensive or lipid lowering medication

Treatment and study plan

The acute effects of dietary fat on lipid profile, insulin sensitivity and inflammatory markers

Dietary Supplement

Primary outcomes

  1. Triacylglycerol (TAG)

    Time frame: 4 h

Secondary outcomes

  1. Insulin sensitivity (glucose, insulin), non-esterified fatty acids (NEFA), inflammatory markers

    Time frame: 4 h

Sponsors and collaborators

Lead sponsor

Malaysia Palm Oil Board

Other Gov

Collaborators

  • University of Malaya

Registry information

Important dates

Study start
2009
Primary completion
2009
Study completion
2009
First posted
May 17, 2010
Registry last updated
May 17, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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