The Acute Cardiovascular Effects of Marathon Running Using Magnetic Resonance Imaging

Using blood testing and cardiac magnetic resonance imaging (MRI), the investigators aim to determine if there are necrotic areas of myocardium in participants who complete a marathon. In addition, the investigators aim to describe the acute and chronic structural abnormalities that occur as a result of endurance training. The study hypothesis is that myocardial necrosis is present in runners completing a marathon competition.

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Key information

Conditions

Myocardial Ischemia Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Artery Disease Coronary Disease Elevated Cardiac Enzymes Heart Diseases Left Ventricular Systolic Dysfunction Vascular Diseases Ventricular Dysfunction Ventricular Dysfunction, Left

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

William Beaumont Hospital

Royal Oak, Michigan, 48009, United States

About this study

MARATHON-MI is a prospective, observational study of twenty-five (25) participants with plans of completing the Detroit Free Press Marathon in Detroit, Michigan on October 19, 2008. All participants will undergo a rigorous pre-marathon screening process which will include: 1) blood testing, 2) complete cardiopulmonary exercise testing, 3) ECG testing, 4) Holter monitoring, 5) cardiac MRI. Blood work will be check after the marathon immediately after and one day after the event. Cardiac MRI will be repeated within 12 hours of finishing the marathon. Using the information derived from the blood work and radiological testing, we will attempt to determine if there is an association between marathon running and myocardial necrosis.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Detroit Free Press Marathon participant on October 19, 2008,
Age > 18 years old,
Ability to provide informed consent.

Exclusion criteria

Known coronary or structural heart disease
Pregnancy,
Extreme claustrophobia,
Metal implants,
Renal dysfunction.

Sponsors and collaborators

Lead sponsor

Corewell Health East

Other

Registry information

Acronym: MARATHON-MRI

Important dates

Study start: 2008
Primary completion: 2010
Study completion: 2010
First posted: Sep 15, 2008
Registry last updated: Apr 3, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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