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OpenTrials
Completed

NCT Number: NCT03449186

Th17 Inducing Cytokines Pregnancy and After Postpartum

The aim of this study was to investigate salivary and gingival crevicular fluid (GCF) levels of IL-17A, IL-17E, IL-6 AND IL-23 during 2/3 trimester of pregnancy and after delivery.

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Key information

Conditions

Pregnancy Mouth Diseases Periodontal Diseases Periodontitis Stomatognathic Diseases

Age range

19 year–40 year

Sex eligibility

Female

Study type

Observational

About this study

IL-17 have a synergytic effect with IL-6 and IL-23. IL-17A levels elevated with periodontal diseases. Many systemical chronic conditions such as atherosclerosis and cardiovascular disease, pregnancy may contribute increasing of IL-17 family cytokine.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • women 2 and 3 trimester of their pregnancy

Exclusion criteria

  • any known systemic disease,
  • periodontal treatment within the last six months,
  • patients having less than 10 teeth,
  • smokers,
  • individuals with a BMI > 30 kg/m2,
  • gestational diabetes and preeclampsia during pregnancy.

Treatment and study plan

Saliva Collection

Other

GCF collection

Other

Primary outcomes

  1. Changing Il-17A levels

    Time frame: 6 month

    Salivary and GCF level measured by ELISA

Secondary outcomes

  1. Changing IL-6 levels

    Time frame: 6 month

    Salivary and GCF level measured by ELISA

  2. Changing IL-23 levels

    Time frame: 6 month

    Salivary and GCF level measured by ELISA

  3. Changing IL-17E levels

    Time frame: 6 month

    Salivary and GCF level measured by ELISA

Sponsors and collaborators

Lead sponsor

Aydin Adnan Menderes University

Other

Registry information

Official study title

Interleukin-17 and Th17 Inducing Cytokines Exacerbate Periodontal Disease During Pregnancy and Postpartum

Important dates

Study start
2013
Primary completion
2014
Study completion
2018
First posted
Feb 28, 2018
Registry last updated
Feb 28, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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