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NCT Number: NCT07512167

Tetanus Severity Score for Prediction of Mortality in Manifest Tetanus

Three scoring systems will be applied to patients suffering from manifest tetanus and will be related to mortality.

Recruiting

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Key information

Conditions

Tetanus, Manifest Bacterial Infections Bacterial Infections and Mycoses Clostridium Infections Gram-Positive Bacterial Infections Infections Tetanus

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Ain Shams University Hospitals & Demanhour Fever Hospital

Cairo, 11341, Egypt

Location status: Recruiting

Location contact

Sameh M Hakim, MD

CONTACT

[email protected]

+202 26900073

About this study

On admission to the intensive care unit, three scoring systems for tetanus severity will be applied to all patients: the Tetanus Severity Score (TSS), Dakar Score, and Philips Score, and will then be related to the occurrence of in-hospital mortality or survival to hospital discharge.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults (age 18 years old or more).
  • Any sex (male or female), regardless of gender identity.
  • Diagnosis of manifest tetanus according to the WHO criteria (https://www.who.int/news-room/fact-sheets/detail/tetanus), that is the presence of one or both of the following criteria with or without the history of specific wound or injury:
  • Sustained spasm of the facial muscles in which person appears grinning.
  • Painful muscular contractions

Exclusion criteria

  • Age < 18 years.
  • Absent criteria of manifest tetanus, as per the WHO criteria (https://www.who.int/news-room/fact-sheets/detail/tetanus).
  • Incomplete medical record with missing data required to calculate the Tetanus Severity Score, Philips Score, or Dakar score.
  • Incomplete medical record with missing data regarding the primary outcome measure (survival to hospital discharge or in-hospital mortality).

Treatment and study plan

Tetanus Severity Score (TSS)

Diagnostic Test

The Tetanus Severity Score (TSS) is calculated for each patient by the investigator using the required data as documented in the medical records at admission

Philips Score

Diagnostic Test

The Philips Score is calculated for each patient by the investigator using the required data as documented in the medical records at admission

Dakar Score

Diagnostic Test

The Dakar Score is calculated for each patient by the investigator using the required data as documented in the medical records at admission

Primary outcomes

  1. Death from any cause.

    Time frame: From the date of onset of symptoms until the date of death or date of discharge from the hospital, whichever comes first, assessed up to 90 days.

    Occurrence of death from any cause, assessed from the date of onset of symptoms up to 90 days.

Study contacts

Contact information is provided by the study sponsor or research team.

Sameh M Hakim, MD

CONTACT

[email protected]

+202 26900073

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Comparison of Three Scoring Systems for Prediction of Mortality in Patients Admitted to the Intensive Care Unit With Manifest Tetanus

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 6, 2026
Registry last updated
May 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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