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Completed

NCT Number: NCT04554342

Testing of a Candy in Five Different Versions for the Additional Humidification of the Oral Cavity

This study is to investigate whether a candy can increase moisture of the oral cavity and reduce dryness of mouth.

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Key information

Conditions

Xerostomia Dryness of Mouth Mouth Diseases Salivary Gland Diseases Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Universitäres Zentrum für Zahnmedizin Basel

Basel, 4058, Switzerland

About this study

A candy (available on the market from a Swiss manufacturer (Ricola)), free of ingredients that could interfere with the investigation, is tested in five different versions on different days. It is to analyse whether these candies can increase moisture of the oral cavity and reduce dryness of mouth.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • non- smoker
  • no allergies
  • no drug- use (except for contraception)
  • healthy volunteers (no disease/infection 4 weeks before study participation)

Exclusion criteria

  • pregnant women

Treatment and study plan

V01 candy

Other

candy with sweetener (Isomalt) and apple flavour

V02 candy

Other

candy with with sweetener (Isomalt) and apple flavour and acidifying agent (apple acid + citric acid)

V03 candy

Other

candy with with sweetener (Isomalt) and apple flavour and acidifying agent (apple acid + citric acid) and Vitamin C

V04 candy

Other

candy with sweetener (Isomalt) (control group 1)

V05 candy

Other

candy with with sweetener (Isomalt) and acidifying agent (apple acid + citric acid) (control group 2)

Primary outcomes

  1. dryness of mouth- sensation

    Time frame: one point assessment following consumption of candy (approx 5 minutes)

    dryness of mouth- sensation by Visual analogue scale (VAS); 0 = does not apply; 10 = is absolutely true.

  2. Change in salivary flow rate (ml/min)

    Time frame: before and after consumption of candy (approx 5 minutes for each salivary flow measurement)

    Change in salivary flow rate (ml/min) before and after stimulation (mechanical and gustatory) by consumption of candy

Sponsors and collaborators

Lead sponsor

University Hospital, Basel, Switzerland

Other

Registry information

Official study title

Testing of a Candy in Five Different Versions for the Additional Humidification of the Oral Cavity (DESERTO)

Acronym: DESERTO

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Sep 18, 2020
Registry last updated
Feb 21, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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