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OpenTrials
Completed

NCT Number: NCT05558072

Testicular Torsion

Background:

Testicular torsion is a scrotal emergency that results in impaired blood supply to the testis and ischemia of the testis as a result of the rotation of the spermatic cord around itself. The etiology of testicular torsion is not clear, but various predisposing factors are responsible for the occurrence of testicular torsion.

Recently, with the discovery of "Toll-Like Receptors" (TLRs), new horizons have been opened in the field of innate immune system-related diseases.

Objective: To mediate the relationship between testicular torsion and TLR4 receptors.

Material-Method: Testicular specimens of patients who developed testicular ischemia after testicular torsion and underwent orchiectomy between 2012-2022 were reached. A study of TLR 4 receptors was performed in these testicular specimens. The patients were divided into two groups according to their ages newborns and adolescents.

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Key information

Conditions

Testicular Torsion and TLR 4 Was Investigated Genital Diseases Genital Diseases, Male Male Urogenital Diseases Spermatic Cord Torsion Urogenital Diseases

Age range

0 day–16 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

About this study

Analysis of 32 newborns and 32 adolescents between the ages of 14 and 16 (mean age was 15.17 ± 0.98) testicular tissue lysate using Toll-Like Receptor antibody 4 (TLR4) ELISA (Enzyme-Linked ImmunoSorbent Assay).

Toll-like receptor 4 is a transmembrane protein that in humans is encoded by the TLR4 gene. Its activation leads to the production of inflammatory cytokines.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

testicular torsion

  • newborn, adolescent,

Exclusion criteria

  • orchitis, urinary infection, trauma,

Treatment and study plan

Toll-like receptor 4

Genetic

Toll-like receptor 4

Primary outcomes

  1. Toll-like receptor 4 positives or negative

    Time frame: 10 years

    testicular torsion

Sponsors and collaborators

Lead sponsor

Hisar Intercontinental Hospital

Other

Registry information

Official study title

Is There a Toll-like 4 Receptor Relationship in Patients With Testicular Torsion?

Important dates

Study start
2012
Primary completion
2021
Study completion
2022
First posted
Sep 28, 2022
Registry last updated
Sep 28, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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