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NCT Number: NCT06587477

Testicular Function and Semen Quality in Male Childhood and Adolescent Cancer Survivors

Cancer treatment can affect the testicular function, including sperm and hormonal functions. The aim of this study is to assess the testicular function and semen quality in young men who recover from childhood and adolescent cancer in Hong Kong. This can provide more information for pre-treatment counselling as well as improve post treatment survivorship care. The testicular function will be compared to aged-matched controls from men attending the Family Planning Association for premarital check-up.

Recruiting

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Key information

Conditions

Cancer, Treatment-Related Late Effect Neoplasms Neoplasms, Second Primary Semen Analysis

Age range

18 year–50 year

Sex eligibility

Male

Study type

Observational

Primary location

Queen Mary Hospital

Hong Kong, China

Location status: Recruiting

Location contact

Jennifer Ko

CONTACT

[email protected]

22554647

About this study

This is a cohort observational study. The target population for the trial will be men who have received chemotherapy and/ or radiotherapy for cancer diagnosed when they were < 18 years old, currently > 18 years old to 50 years old and cancer in remission for at least 2 years. The testicular function, including sperm and hormonal functions, will be compared with aged-matched controls from men attending the Family Planning Association for premarital check-up.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men who have received chemotherapy and/ or radiotherapy for cancer diagnosed when they were < 18 years old.
  • > 18 years old to 50 years old
  • Cancer in remission for at least 2 years

Exclusion criteria

  • Unable to ejaculate by masturbation to provide semen samples
  • Cryptorchidism, testicular cancer, history of vasectomy
  • On testosterone replacement therapy
  • Refusal to join the study

Treatment and study plan

Hormonal profile

Other

Blood for FSH, LH, testosterone

Semen analysis

Other

Semen analysis

Questionnaire

Other

The European Male Ageing Study (EMAS) questionnaire

Primary outcomes

  1. Sperm concentration

    Time frame: up to 3 months

    Sperm concentration

Secondary outcomes

  1. Semen parameters

    Time frame: up to 3 months

    Based on the WHO criteria

Other outcomes

  1. Testicular volume

    Time frame: up to 3 months

    Measured with the Prader orchidometer

  2. Hormonal profile

    Time frame: up to 3 months

    Serum level of testosterone

Study contacts

Contact information is provided by the study sponsor or research team.

Jennifer Ko

CONTACT

[email protected]

22554647

Sponsors and collaborators

Lead sponsor

The University of Hong Kong

Other

Collaborators

  • Hong Kong Children's Hospital
  • Prince of Wales Hospital, Shatin, Hong Kong
  • Queen Mary Hospital, Hong Kong

Registry information

Official study title

Effect of Cancer Treatment on Testicular Function and Semen Quality in Male Childhood and Adolescent Cancer Survivors

Important dates

Study start
2023
Primary completion
2027
Study completion
2028
First posted
Sep 19, 2024
Registry last updated
Sep 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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