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OpenTrials
Completed

NCT Number: NCT02177669

Test-Retest Variability of Quick Contrast Sensitivity Function Testing

The contrast sensitivity function (CSF) provides a comprehensive characterization of spatial vision and predicts functional vision better than visual acuity, but long testing times prevent its psychophysical assessment in clinical applications. Dr. Luis Lesmes et al. (2010) developed the qCSF method to obtain precise CSF measurements in only 30-50 trials using a computerized software program that presents letters on a large monitor that are identified by a patient similar to typical visual acuity testing with an eye chart. The quick CSF method is a Bayesian adaptive method that estimates the full shape of the CSF, and the test duration is only about 3-6 minutes. Some preliminary testing has been performed at other sites with this test in patients with vision loss due to amblyopia and glaucoma, but data from individuals without eye disease who have normal visual acuity has not been systematically collected with the latest version of this test procedure across a wide range of ages. In addition, we aim to gain a better understanding of the typical test-retest variability that is obtained between-sessions that are about a week apart from individuals with good ocular health and visual acuity.

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Key information

Conditions

Healthy

Age range

20 year–89 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Nova Southeastern University; College of Optometry

Fort Lauderdale, Florida, 33328, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Ages 20-89
  • Normal distance visual acuity in each of both eyes (20/20)
  • Absence of ocular disease
  • Able and willing to complete contrast sensitivity testing
  • Provide informed consent

Exclusion criteria

  • Any ocular disease
  • Refractive errors >6D
  • Inability to understand study or communicate responses (cognitive impairment)
  • Unable to understand, read and speak English fluently

Treatment and study plan

quick Contrast Sensitivity Function test

Other

Primary outcomes

  1. 95% coefficient of repeatability across subjects

    Time frame: test-retest at 2 visits about a week apart

    We will evaluate various contrast sensitivity metrics that are generated by the computer program: (i) AULCSF or area under the curve for the log contrast sensitivity function (CSF), (ii) CSF acuity or the cutoff-frequency at which sensitivity=2.0 is calculated, and (iii) contrast sensitivity at various spatial frequencies (i.e. 1.5, 3, 6, 12, 18.5 cycles per degree), obtained with testing performed binocularly, with the better eye monocularly, and with the better eye using a NoIR 4% transmission filter. Within subject, the data will be analyzed as differences between the two values obtained at the two sessions, which can then be used to determine a 95% coefficient of repeatability across subjects.

Sponsors and collaborators

Lead sponsor

Nova Southeastern University

Other

Collaborators

  • Adaptive Sensory Technology

Registry information

Important dates

Study start
2014
Primary completion
2016
Study completion
2016
First posted
Jun 30, 2014
Registry last updated
Apr 11, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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