Skip to main content
OpenTrials
Recruiting

NCT Number: NCT03674645

Test and Optimization of New Specific MRI Sequences on an Imager Dedicated to Research

Magnetic Resonance Imaging (MRI) performance depends on equipment performance, equipment maintenance and relevance of MRI sequence used. To optimize MRI performance, it's necessary to develop, optimize, test and validate new acquisition sequences for enhanced diagnosis and therapy monitoring. These new sequences will allow better spatial resolution and specificity while reducing acquisition time.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Magnetic Resonance Imaging Sequences

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

The purpose of the present study is to test and optimize, on healthy subjects, specific MRI acquisition sequences firstly developed in a preclinical phase on phantoms (inert objects containing solutions or gels) and animal (Pig, sheep). This study will allow the investigators to define practical acquisition parameters that will allow reproducible results and precise definition of clinically relevant examination protocols for each new developed sequence.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy volunteers (over 18 yo),
  • Male or female,
  • Affiliated to social security,
  • Without any contraindication to MRI exam and who will have signed a written inform consent.

Exclusion criteria

  • Individuals deprived of liberty,
  • Under guardianship or curatorship,
  • Persons with known disease which could disturb MRI acquisition or with absolute or relative contraindication to an MRI examination
  • Pregnant women,
  • Breastfeeding women,
  • Women without effective contraception,
  • Participants who refused to be informed of the possible discovery of a significant anomaly,
  • Persons involved in an interventional study with a drug or an implantable device.

Treatment and study plan

MRI acquisitions

Device

Procedure of the study is an MRI exam without any injection or invasive procedure, that will be performed on the Siemens Magnetom Aera imager of Liryc institute (L'Institut de RYthmologie et modélisation Cardiaque) (Xavier Arnozan site - Bordeaux)

Primary outcomes

  1. Image quality

    Time frame: Day 0

  2. Signal to noise ratio

    Time frame: Day 0

  3. Contrasts between structurally different regions

    Time frame: Day 0

    The values of the signal intensities will be measured in adjacent structures of interest. The difference between these values divided by the noise will be calculated to quantify the contrast-to-noise ratio between these structures. The higher this value is, the better is the sequence in its ability to differentiate these structures from one another.

  4. Total acquisition time

    Time frame: Day 0

  5. Qualitative interpretation of image quality to respiratory and cardiac motions

    Time frame: Day 0

    In the presence of improper compensation for cardiac and / or respiratory movements, the images may appear blurred. The qualitative interpretation of image quality will be performed by visual image analysis.

  6. Quantitative interpretation of image quality to respiratory and cardiac motions

    Time frame: Day 0

    In the presence of improper compensation for cardiac and / or respiratory movements, the images may appear blurred. The quantitative interpretation of image quality will be performed by a measurement of sharpness of contours between adjacent structures of interest.

Study contacts

Contact information is provided by the study sponsor or research team.

Hubert COCHET, MD

CONTACT

[email protected]

(0)557675613 ext. +33

Lorena SANCHEZ BLANCO, MD

CONTACT

[email protected]

(0)557623091 ext. +33

Sponsors and collaborators

Lead sponsor

University Hospital, Bordeaux

Other

Collaborators

  • L'Institut de RYthmologie et modélisation Cardiaque (IHU LIRYC)

Registry information

Acronym: SEQ-IRM

Important dates

Study start
2018
Primary completion
2028
Study completion
2028
First posted
Sep 17, 2018
Registry last updated
Mar 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.