TEMPUS ARIES: A Biobank Registry Platform Study in Oncology

This study is a non-interventional, multicenter, multicohort evaluation of participants with cancer who will undergo longitudinal plasma ctDNA biomarker profiling at specific time points in addition to standard of care therapy.

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Key information

Conditions

Cancer Neoplasms

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Pan American Center for Oncology Trials, Rio Piedras, Puerto Rico

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

≥18 years of age
Willing to participate in the research
Able to provide informed consent
Must be diagnosed with cancer

Exclusion criteria

Not willing or able to have additional blood samples collected

Treatment and study plan

Primary outcomes

Changes in ctDNA from baseline, on-treatment and post-treatment blood samples.

Time frame: 5 years

Assess ctDNA kinetics using ctDNA clearance factors such as time to clearance, best overall clearance rate, best confirmed clearance, and time to ctDNA recurrence and correlate with standard of care therapy real-world outcomes such as overall survival, progression-free survival, time to next treatment, and time to treatment discontinuation.

Secondary outcomes

Generation of DNA, RNA, immune and other multiomic datasets.

Time frame: 5 years

Use blood and tissue based next generation sequencing to uncover biomarkers that may predict outcomes, identify markers related to disease, identify markers related to mechanism of drug action, and inform future research.

Study contacts

Contact information is provided by the study sponsor or research team.

Lauren Lopez

CONTACT

[email protected]

8007394137

Sponsors and collaborators

Lead sponsor

Tempus AI

Industry

Registry information

Important dates

Study start: 2024
Primary completion: 2029
Study completion: 2029
First posted: Jan 16, 2024
Registry last updated: Feb 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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