Northwest Normal University
Lanzhou, Gansu, 730070, China
Location status: Recruiting
Location contact
Xiaofeng Ma, Professor
CONTACT
NCT Number: NCT06562504
Temporal order memory deficits are a central feature of cognitive abnormalities in schizophrenia. The dorsolateral prefrontal cortex contributes to the extraction of temporal contextual information. Transcranial direct current stimulation (tDCS) and interim testing have been shown to be external techniques that can improve temporal order memory deficits in schizophrenia patients. Transcranial alternating current stimulation (tACS) can also improve cognitive functioning in patients with schizophrenia. This study intends to investigate the learning effects of temporal order memory under two learning strategies during tDCS targeting the left dorsolateral prefrontal cortex (L-DLPFC) and transcranial direct current stimulation (tDCS) interventions in patients with schizophrenia, to investigate whether it can promote the retention of temporal order memory in patients, and to compare the differences in the effects of the two intervention modalities.
This study was planned to recruit 75 patients diagnosed with schizophrenia from the hospital.
A single online tDCS (2 mA × 20 min) and tACS (1.5 mA × 20 min, theta rhythm) intervention was conducted during which participants performed a temporal-sequence memory task for visual pictures, and test scores were compared for each stimulus type on an intermediate test and repetition of the two strategies of learning.
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Request Info18 year–50 year
All sexes
Interventional
Not applicable
Lanzhou, Gansu, 730070, China
Location status: Recruiting
Xiaofeng Ma, Professor
CONTACT
Treatment was conducted by two examiners, and participants' memory levels were tested before the start of the experiment using a flanker task and a numerical breadth task as baseline tests. The experimental procedure was divided into a learning phase, in which participants memorized the sequence of pictures, and a testing phase, in which participants were required to recall a picture presented after the probe item. Participants were randomly assigned in parallel to each stimulus type and learning strategy, with 25 receiving tdcs anodized stimuli, 25 receiving sham stimuli, and another 25 receiving tacs stimuli. And participants' inhibitory control continued to be tested using the flanker task before and after the stimuli for pre- and post-intervention comparisons.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
2mA/20mins/session;
0mA/20mins/session
1.5 mA/20 min/session; 6HZ, theta
Time frame: 5mins to 24 hours
Stimulus content was presented using the Eprime experimental program, and participants pressed key responses during the test phase to record their rate of correctness.
Stimulus content was presented using the Eprime experimental program, and participants pressed key responses during the test phase to record their rate of correctness.
Time frame: 5mins to 24 hours
The rate of intrusion of prior information when participants recalled the current information was counted.
Contact information is provided by the study sponsor or research team.
Xiaofeng Ma
Other
Transcranial Electrical Stimulation Combined With Interim Testing Promotes Temporal Memory in Patients With Schizophrenia
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