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NCT Number: NCT06562504

Temporal Memory in Schizophrenic Patients

Temporal order memory deficits are a central feature of cognitive abnormalities in schizophrenia. The dorsolateral prefrontal cortex contributes to the extraction of temporal contextual information. Transcranial direct current stimulation (tDCS) and interim testing have been shown to be external techniques that can improve temporal order memory deficits in schizophrenia patients. Transcranial alternating current stimulation (tACS) can also improve cognitive functioning in patients with schizophrenia. This study intends to investigate the learning effects of temporal order memory under two learning strategies during tDCS targeting the left dorsolateral prefrontal cortex (L-DLPFC) and transcranial direct current stimulation (tDCS) interventions in patients with schizophrenia, to investigate whether it can promote the retention of temporal order memory in patients, and to compare the differences in the effects of the two intervention modalities.

This study was planned to recruit 75 patients diagnosed with schizophrenia from the hospital.

A single online tDCS (2 mA × 20 min) and tACS (1.5 mA × 20 min, theta rhythm) intervention was conducted during which participants performed a temporal-sequence memory task for visual pictures, and test scores were compared for each stimulus type on an intermediate test and repetition of the two strategies of learning.

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Key information

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Northwest Normal University

Lanzhou, Gansu, 730070, China

Location status: Recruiting

Location contact

Xiaofeng Ma, Professor

CONTACT

About this study

Treatment was conducted by two examiners, and participants' memory levels were tested before the start of the experiment using a flanker task and a numerical breadth task as baseline tests. The experimental procedure was divided into a learning phase, in which participants memorized the sequence of pictures, and a testing phase, in which participants were required to recall a picture presented after the probe item. Participants were randomly assigned in parallel to each stimulus type and learning strategy, with 25 receiving tdcs anodized stimuli, 25 receiving sham stimuli, and another 25 receiving tacs stimuli. And participants' inhibitory control continued to be tested using the flanker task before and after the stimuli for pre- and post-intervention comparisons.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Meeting the diagnostic criteria for schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5);
  • Aged 18 years or older, regardless of gender, with an educational level of elementary school or above;
  • All patients received stable-level antipsychotic medication treatment, were in a stable phase of disease treatment, able to understand the testing requirements, and cooperated to complete all research tasks;
  • No history of neurological disorders or other serious physical illnesses, and no history of intellectual disability;
  • No color blindness, color weakness, or other color vision impairments, with normal vision or corrected vision.

Exclusion criteria

  • Clear cognitive impairment caused by somatic or cerebral organic lesions, such as cerebrovascular diseases, traumatic brain injury, etc;
  • Individuals with mental disorders caused by substance dependence or abuse, or the use of psychoactive substances;
  • History of brain injury or other central nervous system-related organic diseases;
  • Individuals at significant risk of suicide or harming others;
  • Participation in similar experiments in the past 30 days prior to baseline.

Treatment and study plan

Transcranial direct current stimulation (tDCS)- anodal group

Device

2mA/20mins/session;

Transcranial direct current stimulation (tDCS)- sham group

Device

0mA/20mins/session

transcranial alternating current stimulation (tACS)-tACS group

Device

1.5 mA/20 min/session; 6HZ, theta

Primary outcomes

  1. Correctness of temporal recall

    Time frame: 5mins to 24 hours

    Stimulus content was presented using the Eprime experimental program, and participants pressed key responses during the test phase to record their rate of correctness.

    Stimulus content was presented using the Eprime experimental program, and participants pressed key responses during the test phase to record their rate of correctness.

  2. proactive interference rate

    Time frame: 5mins to 24 hours

    The rate of intrusion of prior information when participants recalled the current information was counted.

Study contacts

Contact information is provided by the study sponsor or research team.

Tiantian Li, Doctor

CONTACT

[email protected]

13909483531

Sponsors and collaborators

Lead sponsor

Xiaofeng Ma

Other

Registry information

Official study title

Transcranial Electrical Stimulation Combined With Interim Testing Promotes Temporal Memory in Patients With Schizophrenia

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Aug 20, 2024
Registry last updated
Aug 20, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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