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NCT Number: NCT07082101

Temporal Interference for Temporal Lobe Epilepsy Under SEEG

This study evaluates the effect of temporal interference (TI) stimulation on biomarkers in patients with temporal lobe epilepsy (TLE) under stereo-electroencephalography (SEEG), and provides theoretical basis for non-invasive TI treatment of temporal lobe epilepsy.

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Key information

Conditions

Epilepsy Brain Diseases Central Nervous System Diseases Nervous System Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

10 patients aged 18-65 years with TLE assessed by semiology, video electroencephalogram and imaging in Epilepsy Center of Xijing Hospital (Xi'an, China) will be recruited. Clinical baseline data such as general information and history of seizures will be collected. The SEEG electrodes were implanted in the Department of neurosurgery of Xijing Hospital and after 24 hours TI will be performed with continuous SEEG monitoring. Finally, the biomarker changes of EEG signals before and after TI treatment were statistically analyzed.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of drug refractory epilepsy and temporal lobe epilepsy;
  • Patients undergoing SEEG;
  • Able to cooperate the treatment and related inspection;
  • Fully understands and signs informed consent.

Exclusion criteria

  • Patients with temporal plus epilepsy;
  • In status epilepticus;
  • With other severe disease;
  • Pregnancy or lactation women;
  • Unable to tolerate SEEG or TI;
  • At the same time to participate in other clinical trials;
  • Withdraw consent procedure.

Treatment and study plan

Temporal Interference

Other

In this intervertion, patients with SEEG operation will take temporal interference (TI) stimulation and the deep brain EEG will be monitorated through the entire experiment.

Primary outcomes

  1. Number of interictal electrophysiological biomaker changes in epilepsy

    Time frame: 24 hours after TI stimulation

    Electrophysiological biomarkers changes recorded by SEEG through the experiment.

Study contacts

Contact information is provided by the study sponsor or research team.

Wen Jiang

CONTACT

[email protected]

+86-02984773664

Sponsors and collaborators

Lead sponsor

Xijing Hospital

Other

Registry information

Official study title

Evaluating Biomarkers of Temporal Interference for Temporal Lobe Epilepsy Under SEEG

Acronym: TITE-SEEG

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jul 24, 2025
Registry last updated
Jul 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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