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Completed

NCT Number: NCT05866224

Telerehabilitation Program and Detraining in Patients With Post-COVID-19 Sequelae

The primary objective of this study is to evaluate the effects of a 15-week home telerehabilitation program and a detraining period on cardiorespiratory fitness and muscular efficiency in patients with post-COVID-19 sequelae compared to a control group of COVID-19 patients. We hypothesize that cardiorespiratory fitness and muscular efficiency significantly improve in patients who carry out the home telerehabilitation program. However, the cardiorespiratory and muscular adaptations achieved and tolerance to exercise are lost over time as an effect of detraining.

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Key information

Conditions

COVID-19 Acute Respiratory Distress Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Manuel Vicente Garnacho Castaño

Sant Boi de Llobregat, Barcelona, 08830, Spain

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age > 18 years
  • molecular diagnosis (reverse transcription polymerase chain reaction [RT-PCR]) of infection by SARS-CoV-2
  • post-COVID-19 symptomatology

Exclusion criteria

  • severe neurological disease
  • active oncological disease
  • neuromuscular disease and/or orthopedic disorders impeding normal development of cardiopulmonary exercise test
  • the absence of signed informed consent

Treatment and study plan

Telerehabilitation program

Other

The supervised telerehabilitation program will be performed in the home of each patient and supervised by an experienced physiotherapist with more than 4 years of clinical experience in therapeutic exercise for chronic diseases.

Primary outcomes

  1. Cardiorespiratory fitness: absolute oxygen uptake

    Time frame: 1 week per group

    absolute peak oxygen uptake in L/min

  2. Cardiorespiratory fitness: relative oxygen uptake

    Time frame: 1 week per group

    relative peak oxygen uptake in L/min

  3. Exercise capacity during cardiopulmonary exercise test

    Time frame: 1 week per group

    Exercise time in minutes and seconds

  4. Mechanical efficiency

    Time frame: 1 week per group

    Delta efficiency in percentage

  5. Ventilatory efficiency

    Time frame: 1 week per group

    VE/VCO2 slope

  6. Power output during pedaling

    Time frame: 1 week per group

    Power output in watts

Secondary outcomes

  1. Respiratory exchange ratio

    Time frame: 1 week per group

    RER

  2. Minute ventilation

    Time frame: 1 week per group

    Ventilation in L/min

  3. ventilatory equivalent for oxygen

    Time frame: 1 week per group

    VE/VO2

  4. ventilatory equivalent for carbon dioxide

    Time frame: 1 week per group

    VE/VCO2

  5. End-tidal partial pressure of oxygen

    Time frame: 1 week per group

    PetO2 in mmHg

  6. end-tidal partial pressure of carbon dioxide

    Time frame: 1 week per group

    PetCO2 in mmHg

  7. Weight of COVID-19 patients

    Time frame: 1 week per group

    Weight in kg

  8. Height of COVID-19 patients

    Time frame: 1 week per group

    Height in meters

  9. Body mass index of COVID-19 patients

    Time frame: 1 week per group

    BMI in kg/m2

Sponsors and collaborators

Lead sponsor

Campus docent Sant Joan de Déu-Universitat de Barcelona

Other

Registry information

Official study title

Effects of a Telerehabilitation Program and Detraining on Cardiorespiratory Fitness in Patients With Post-COVID-19 Sequelae

Important dates

Study start
2021
Primary completion
2023
Study completion
2023
First posted
May 19, 2023
Registry last updated
May 19, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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