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NCT Number: NCT07539571

Telerehabilitation in Patients With Bronchiectasis

Background: Home-based telerehabilitation (TR) has demonstrated benefits comparable to conventional rehabilitation in patients with chronic obstructive pulmonary disease, asthma, and pulmonary fibrosis. However, TR has not been thoroughly investigated in patients with bronchiectasis, despite evidence suggesting improvements in exercise capacity and quality of life.

Aims: To evaluate the effects of TR on functional capacity, quality of life, and inflammatory biomarkers, as well as its safety in patients with bronchiectasis.

Study design: Single-center randomized controlled trial with a parallel-group design.

Methods: Patients diagnosed with bronchiectasis will be recruited from the Surgical Medical Unit for Respiratory Diseases at Virgen del Rocío University Hospital. Participants will be randomly assigned to one of two groups: a control group receiving usual care, and a TR group undergoing supervised physical training for 12 weeks, three times per week. Outcome measures will include the 6-minute walk test, quality-of-life questionnaires, pulmonary function tests, symptom assessment, and adverse event recording, as well as sputum microbiology and analysis of inflammatory biomarkers. Assessments will be conducted at baseline and at the end of the intervention.

Expected results: A 12-week TR program is expected to significantly improve exercise capacity and quality of life in the intervention group. Additionally, this study may contribute to the development of future clinical guidelines regarding the use of TR in patients with bronchiectasis.

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Key information

Conditions

Bronchiectasis Bronchial Diseases Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Respiratory Tract Diseases Telerehabilitation

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hospital Universitario Virgen del Rocío

Seville, Sevilla, 41013, Spain

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Bronchiectasis diagnosed by high resolution computed tomography (HRCT) of the chest.
  • Clinically stable patients (without hospitalizations, infection or changes in pharmacological treatment in the last month of the study beginning).
  • Both gender
  • Non smokers.
  • Internet connection available.

Exclusion criteria

  • Inability to give informed consent to participate
  • Less of 18 years
  • With other lung related diseases (asthma, COPD and cystic fibrosis)
  • Decompensated cardiovascular and metabolic diseases, neuromuscular or musculoskeletal that impede the realization of the protocol.
  • Mental disorders that prevent the adequate participation in the tele-rehabilitation program.
  • Simultaneous participation in another clinical trial.

Treatment and study plan

telerehabilitation

Other

3 days per week: supervised resistance training that includes upper and lower limb and core exercises, initially using with low weights, performed in 2 sets with 10 repetitions, with progressive weekly increases depending on symptoms.

4 days per week: endurance training. Patients will walk on days when they do not perform strength training, for at least 30 minutes, with the duration gradually increased each month depending on their symptoms.

Other names: physical activity

Primary outcomes

  1. 6-minute walk distance

    Time frame: Baseline, week 6, after 12 weeks of telerehabilitation program, and at 3 and 6 months after completing the telerehabilitation program.

    Patients walk through a 30-meter corridor faster than they can for 6 minutes

Secondary outcomes

  1. The quality of life

    Time frame: Baseline, after 12 weeks of telerehabilitation program and at 3 and 6 months after completing the telerehabilitation program.

    ST Georges respiratory questionnaire COPD assessment test. Scores range from 0 to 100, where 0 represents the best possible health (no limitations) and 100 the worst health status.

  2. Pulmonary function tests

    Time frame: Baseline and after 12 weeks of telerehabilitation program.

    pulmonary function tests (FEV1, FVC)

  3. Respiratory Muscle Strength

    Time frame: Baseline and after 12 weeks of telerehabilitation program.

    Maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP).

  4. Exahled Nitric Oxide Fraction (FeNO)

    Time frame: Baseline and after 12 weeks of telerehabilitation program.

    Exahled Nitric Oxide Fraction (FeNO)

  5. Sputum microbiology

    Time frame: Baseline, after 12 weeks of telerehabilitation program, and at 3 and 6 months after completing the telerehabilitation program.

    The presence of Pseudomonas Aeruginosa through microbiological analysis of sputum

  6. Biological markers of Biological markers of inflammation

    Time frame: Baseline and after 12 weeks of telerehabilitation program.

    PCR, neutrophil/lymphocyte ratio, IL-1β, IL-6, TNF-α levels.

  7. Dyspnoea

    Time frame: Baseline, week 6, after 12 weeks of telerehabilitation program, and at 3 and 6 months after completing the telerehabilitation program.

    Modified Medical Research Council (mMRC) dyspnoea scale. Minimum value (Grade 0): Absence of dyspnea. Maximum value (Grade 4): Severe dyspnea.

  8. Bronchiectasis severity

    Time frame: Baseline and after 12 weeks of telerehabilitation program.

    The E-FACED questionnaire. Scores range from 0 to 9, where a score of 0-3 indicates mild severity, 4-6 indicates moderate severity, and ≥ 7 indicates severe disease.

  9. Change from baseline in respiratory symptoms and adverse events.

    Time frame: Baseline, week 6, after 12 weeks of telerehabilitation program, and at 3 and 6 months after completing the telerehabilitation program.

    Change from baseline in respiratory symptoms and adverse events.

  10. Blood pressure

    Time frame: Baseline, week 6, after 12 weeks of telerehabilitation program, and at 3 and 6 months after completing the telerehabilitation program.

    Measurement of blood pressure using a sphygmomanometer.

    Blood Pressure Ranges in Adults:

    Normal: Less than 120/80 mmHg. Elevated: 120-129 / < 80 mmHg. Hypertension Grade 1: 130-139 / 80-89 mmHg. Hypertension Grade 2: ≥ 140 / ≥ 90 mmHg.

  11. Heart rate

    Time frame: Baseline, week 6, after 12 weeks of telerehabilitation program, and at 3 and 6 months after completing the telerehabilitation program.

    The heart rate value recorded by the sphygmomanometer will be documented.

  12. Oxygen saturation (SpO2)

    Time frame: Baseline, week 6, after 12 weeks of telerehabilitation program, and at 3 and 6 months after completing the telerehabilitation program.

    Oxygen saturation is measured using a pulse oximeter. Values between 95% and 100% are considered normal. Values below 90% are considered hypoxemia.

    Normal values range between 95% and 100%.

  13. Exacerbation

    Time frame: Baseline, week 6, after 12 weeks of telerehabilitation program, and at 3 and 6 months after completing the telerehabilitation program.

    Exacerbation rate

  14. Telerehabilitation adherence

    Time frame: Baseline, week 6, after 12 weeks of telerehabilitation program, and at 3 and 6 months after completing the telerehabilitation program.

    Number of sessions completed by participants who take part in the rehabilitation program and training parameters registration

Sponsors and collaborators

Lead sponsor

Hospitales Universitarios Virgen del Rocío

Other

Registry information

Official study title

Effectiveness of a 12-week Telerehabilitation Training in Patients With Bronchiectasis: A Randomized Controlled Trial.

Important dates

Study start
2026
Primary completion
2031
Study completion
2032
First posted
Apr 20, 2026
Registry last updated
Apr 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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