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NCT Number: NCT05779605

Telerehabilitation in Hemato-oncological Survivors

This study investigates whether the 12-week home-based exercise training with remote guidance and telemonitoring compared to regular center-based training leads to better long-term cardiorespiratory fitness and physical activity levels in post-treatment patients with lymphoma.

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Key information

Conditions

Hematologic Malignancy Hematologic Diseases Hematologic Neoplasms Hemic and Lymphatic Diseases Immune System Diseases Immunoproliferative Disorders Lymphatic Diseases Lymphoma Lymphoproliferative Disorders Neoplasms Neoplasms by Histologic Type Neoplasms by Site

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

80 lymphoma cancer patients post-treatment (except adjuvant treatment) will be enrolled in the study. Cardiorespiratory fitness (peak oxygen consumption), adverse events, body composition, quality of life, costs and adherence to exercise prescription will be evaluated at baseline, 12-week, and year after enrollment.

Investigators assume that home-based training with remote guidance and telemonitoring with objective training data obtained during rehabilitation after cancer treatment will improve long-term motivation and effectiveness of independent training in cancer survivors, resulting in superior cardiorespiratory fitness and physical activity levels.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Participants

  • with hemato-oncological malignancy / lymphoma (in last two months)
  • after cancer systemic chemotherapy-based treatment
  • with clinically stable state
  • with the ability to perform a cardiopulmonary exercise test
  • with the ability to understand and write in the Czech language
  • with an internet connection at home
  • literacy with information and communication technology

Exclusion criteria

Participants

  • with acute heart disease or decompensation in the previous six weeks,
  • with psychological severe, cognitive disorders,
  • serious training limitations (musculoskeletal disorders)
  • currently carried out the recommendations for physical activity (150min per week)
  • who take part in a training program under supervision elsewhere

Treatment and study plan

Home-based training

Device

Patients will be instructed to perform three weekly training sessions at home (30 to 50 min/session, at an intensity of 70-85% of their maximum heart rate). Patients in the home training group complete the first three training sessions in the clinic under direct supervision. During these sessions, patients are introduced to the duration and intensity of training. The trainer will provide remote guidance (feedback on training frequency, duration, and intensity) via telephone call once a week. During exercise, patients will use a wearable heart rate monitor (Polar M430, a commercially available device designed for long-term use). Patients will be instructed to properly use the wearable sensor and upload training data to a web-based platform (Polar Flow) via the Internet. Furthermore, patients will be asked to choose their preferred training modality at home (cycling, walking, Nordic walking) and receive instructions and advice.

Center-based training

Device

Patients receive three training sessions a week with 30 to 50 min duration at 70 - 90% of their maximal heart rate at the outpatient clinic under direct supervision. Exercise modalities will be walking on a treadmill, riding a bicycle ergometer, and resistance training. Physiotherapists will track the attendance rate and training adherence during the training program.

Primary outcomes

  1. Cardiorespiratory fitness

    Time frame: Change from baseline to 12 weeks and 52 weeks

    Peak oxygen uptake during cardiopulmonary exercise test

Secondary outcomes

  1. Health-related quality of life

    Time frame: Change from baseline to 12 weeks and 52 weeks

    Health-related quality of life (SF-36 Form) yields a score for each domain of health. All domains are scored on a scale from 0 (negative health) to 100 (positive health), with 100 representing the best possible health state

  2. Satisfaction - self-completed questionnaire

    Time frame: 12 weeks and 52 weeks

    Subjects will be provided with a 5-item self-completed questionnaire developed by our research team that will measure their satisfaction with the intervention they received and the study in general. The items will be presented in the form of statements to which subjects will be asked to respond using a 1-5 Likert scale ("strongly agree", "agree", "not sure", "disagree", and strongly disagree").

  3. Body water

    Time frame: Change from baseline to 12 weeks and 52 weeks

    Total body water in liters will be measured by bioelectrical impedance analysis.

  4. Muscle mass

    Time frame: Change from baseline to 12 weeks and 52 weeks

    Total muscle mass in kilograms will be measured by bioelectrical impedance analysis.

  5. Body fat percentage

    Time frame: Change from baseline to 12 weeks and 52 weeks

    Body fat percentage will be measured by bioelectrical impedance analysis.

  6. Incidence of exercise adverse events assessed by 5 grade scale

    Time frame: Data will be recorded continuously from the intervention's baseline for 12 weeks and then for 52 weeks

    Participants will be encouraged to use the contact details for reporting incidence of exercise adverse events at any time throughout the study period. The type, incidence, and severity of adverse events by scale (Grade 1: Mild, asymptomatic or mild symptoms; Grade 2: Moderate, minimal; Grade 3: Severe or medically significant; Grade 4: Life-threatening consequences; and Grade 5: Death) will be noted.

  7. Training adherence (Number of compliant participants)

    Time frame: 12 weeks

    Evaluation of the total number of compliant participants (The criterium of compliance with the rehabilitation program is set at 70% of the prescribed training lessons, 100% = 36 lessons)

  8. Maximum Grip Strength

    Time frame: Change from baseline to 12 weeks and 52 weeks

    Maximum grip strength during dynamometer evaluation

Study contacts

Contact information is provided by the study sponsor or research team.

Katerina Filakova

CONTACT

[email protected]

00420532233123

Sponsors and collaborators

Lead sponsor

Brno University Hospital

Other

Registry information

Official study title

Remotely Monitored Rehabilitation in Hemato-oncological Survivors After Treatment: The Tele@Home Study

Acronym: Tele@home

Important dates

Study start
2023
Primary completion
2025
Study completion
2026
First posted
Mar 22, 2023
Registry last updated
Sep 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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