Skip to main content
OpenTrials
Completed

NCT Number: NCT06295601

Telerehabilitation Based Motor Imagery and Action Observation Training in Multiple Sclerosis

This study aims to investigate the effects of the treatment combination consisting of motor imagery and action observation therapy on balance, functional mobility, lower extremity muscle strength, fatigue and quality of life.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Immune System Diseases Nervous System Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Inonu University

Malatya, Battalgazi, 44280, Turkey (Türkiye)

About this study

The study population was participants with relapsing remitting multiple sclerosis. The traditional rehabilitation program consists of a joint treatment in which lower extremity strengthening and balance exercises are carried out synchronously for the experimental and control groups. Motor imagery and action observation therapy based on telerehabilitation of certain movements will be applied to the experimental group. All treatments will be carried out online via the Whatsapp program. The treatment program will be applied 3 times a week for 6 weeks. Evaluations will be made before and after the treatment program. Assessments include balance, lower extremity muscle strength and functional mobility, fatigue, and quality of life.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Being diagnosed with mulltiple sclerosis according to the McDonald criteria
  • Expanded Disability Status Scale<5.5,
  • Being between the ages of 18-65,
  • Mini mental test score>24,
  • Have a phone that can adapt to participating in a video call

Exclusion criteria

  • Having another additional neurological disease that may cause balance and coordination disorders,
  • having received physical therapy and regularly engaged in sports in the last 6 months
  • Having an attack in the last 3 months
  • Refusal to participate in the study.

Treatment and study plan

traditional rehabilitation

Other

The program consists of a joint treatment in which lower extremity strengthening and balance exercises are carried out synchronously. The program will include a total of 5 minutes of warm-up, 5 minutes of cool-down and 30 minutes of exercises related to the program. The difficulty of the program will increase by changing the number of exercises and increasing the weight in strengthening exercises. Progress in balance and coordination exercises will vary by changing the ground, increasing the standing time, and keeping the eyes open and closed.

Action observation therapy and motor imagery

Other

In the experimental group, in addition to traditional telerehabilitation, action observation and motor imagery of 4 exercises will be performed in each session. A video will be prepared for 4 exercises. Then, the participant will perform 2 minutes of action observation of each movement, followed by 1 minute of motor imagery. In addition to the traditional telerehabilitation program, a 12-minute combination of action observation and motor imagery will be performed in each session. Exercises will be changed every two weeks, gradually increasing the difficulty.

Primary outcomes

  1. Berg Balance Scale

    Time frame: Baseline

    Berg Balance Scale consists of a total of 14 items. Evaluation for each stage is made between 0-4. Higher score indicates better functional balance performance

  2. Berg Balance Scale

    Time frame: 6 weeks after baseline

    Berg Balance Scale consists of a total of 14 items. Evaluation for each stage is made between 0-4. Higher score indicates better functional balance performance

  3. Muscle strength and functional mobility

    Time frame: Baseline

    The participant will be asked to sit and stand up from a standard chair between 42-45 cm, with hands crossed on the chest, without support, 5 times. The time will be stopped when the participant completes the last sitting. It will be recorded in seconds.

  4. Muscle strength and functional mobility

    Time frame: 6 weeks after baseline

    The participant will be asked to sit and stand up from a standard chair between 42-45 cm, with hands crossed on the chest, without support, 5 times. The time will be stopped when the participant completes the last sitting. It will be recorded in seconds.

Secondary outcomes

  1. Fatigue Severity Scale

    Time frame: Baseline

    This scale consists of a total of 9 items and is scored between 0-7. >4 points indicate fatigue

  2. Fatigue Severity Scale

    Time frame: 6 weeks after baseline

    This scale consists of a total of 9 items and is scored between 0-7. >4 points indicate fatigue

  3. Multiple Sclerosis International Quality of Life (MusiQoL) questionnaire

    Time frame: Baseline

    The scale consists of 31 questions in 9 dimensions (subscales). The index score is calculated as the average of these subscale scores. All 9 dimensions and the index score are linearly transformed and standardized on a scale from 0 to 100; where 0 indicates the worst possible level of quality of life and 100 indicates the best level.

  4. Multiple Sclerosis International Quality of Life (MusiQoL) questionnaire

    Time frame: 6 weeks after baseline

    The scale consists of 31 questions in 9 dimensions (subscales). The index score is calculated as the average of these subscale scores. All 9 dimensions and the index score are linearly transformed and standardized on a scale from 0 to 100; where 0 indicates the worst possible level of quality of life and 100 indicates the best level.

Sponsors and collaborators

Lead sponsor

Inonu University

Other

Registry information

Official study title

Effect of Telerehabilitation-Based Motor Imagery and Action Observation Training on Balance and Functional Mobility in Multiple Sclerosis: Randomized Controlled Study

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Mar 6, 2024
Registry last updated
Jun 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.