Telerehab Exerbrain: Bridging Physical and Cognitive Therapy in Stroke

The goal of this clinical trial is to evaluate whether a 12-week, web-based exercise and cognitive (physical-cognitive) training program can improve both physical abilities and brain function in adults with long-term stroke. The study will also examine whether the program is safe, practical to use at home, and enjoyable.

Many people who have had a stroke continue to experience problems with movement (such as walking, balance, weakness, and risk of falling) as well as problems with cognition (such as memory, attention, and problem-solving). Traditional rehabilitation often focuses mainly on physical recovery. This study tests a program that combines physical exercises and cognitive training at the same time using interactive online "exergames" delivered through telerehabilitation.

The main questions this study aims to answer are:

Does the program improve motor function, walking speed, balance, muscle power, and reduce fall risk? Does the program improve cognitive abilities, including global cognitive ability, executive function, memory, and attention? Is the program enjoyable and feasible for people with chronic stroke to use at home? In this study, 52 participants will be randomly assigned to one of two groups. One group will complete the 12-week web-based physical-cognitive training program at home. Another group will continue receiving their usual care. The researchers will compare changes in physical and cognitive performance between the two groups.

Participants in the training group will follow guided exercise sessions delivered online. All participants will complete physical and cognitive assessments before and after the 12-week period. The results of this study may help determine whether web-based physical-cognitive training is an effective and accessible rehabilitation option for people living with chronic stroke.

Inclusion criteria

• diagnosed with ischemic or hemorrhagic stroke at least 6 months before enrollment
• aged between 20 and 80 years
• able to walk at least 10 meters with or without assistive devices
• able to perform sit-to-stand safely with or without assistive devices
• can see the screen of a tablet or notebook computer at a distance of at least 60 cm
• have a stable medical condition and can follow study instructions
• frequent users of a mobile phone, tablet, or notebook computers

Exclusion criteria

• have medical conditions or complications that would be unsafe to exercise
• have neglect, impaired communication, or uncorrected visual problems [30], or - have severe spasticity of the upper or lower extremities (Modified Ashworth Scale ≥ 3)