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OpenTrials
Completed

NCT Number: NCT07546474

Telemedicine-Assisted vs Conventional Telephone Instruction in Cardiopulmonary Resuscitation

Out-of-hospital cardiac arrest (OHCA) is a life-threatening emergency where early cardiopulmonary resuscitation (CPR) by bystanders can significantly improve survival. Emergency dispatchers often guide bystanders to perform CPR over the phone, a method known as dispatcher-assisted CPR (DA-CPR). While this approach has increased bystander CPR rates worldwide, it relies on voice communication only, which may limit the dispatcher's ability to assess the situation and guide CPR effectively.

With advances in telecommunication technology, video-based communication has become more widely available. Telemedicine-assisted CPR (TA-CPR) allows dispatchers or emergency medical providers to see the patient and the rescuer through a live video call, potentially improving CPR performance by providing real-time visual feedback. However, evidence on whether this approach improves outcomes in real-world emergency medical service (EMS) systems is still limited.

This study aims to compare the effectiveness of TA-CPR with conventional DA-CPR in adult patients with suspected non-traumatic OHCA. The study is designed as a pragmatic cluster-randomized controlled trial conducted within a hospital-based EMS system in Bangkok, Thailand. Instead of randomizing individual patients, the CPR instruction protocol is assigned by month (cluster randomization). During each month, all eligible patients receive either the TA-CPR protocol or the DA-CPR protocol.

In both groups, CPR instructions are first provided through voice communication to avoid delaying the start of chest compressions. In the TA-CPR group, responders may switch to video communication if it is feasible, depending on factors such as the caller's device capability and the availability of another person to hold the camera. In the DA-CPR group, only voice communication is used throughout.

The study includes adult patients (aged 18 years or older) with suspected non-traumatic cardiac arrest who are managed by the participating EMS unit. Patients are excluded if resuscitation is declined, if the location is unsafe, if the cardiac arrest is witnessed by EMS personnel, or if communication barriers prevent CPR instructions.

The primary outcome of the study is the proportion of patients who receive bystander CPR before EMS arrival. Secondary outcomes include whether bystanders continue chest compressions until EMS arrives, how well responders follow the assigned protocol, and selected patient outcomes such as return of spontaneous circulation and survival.

Data are collected from an EMS cardiac arrest registry and hospital medical records. Audio recordings of dispatcher and responder communications are reviewed to assess adherence to the study protocols. The results of this study will help determine whether adding video communication to dispatcher-assisted CPR provides additional benefit in real-world EMS settings and inform future implementation of telemedicine in emergency care systems.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Medicine Siriraj Hospital, Mahidol University

Bangkok Noi, Bangkok, 10700, Thailand

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients aged ≥18 years
  • Suspected non-traumatic out-of-hospital cardiac arrest
  • Managed by the participating advanced life support (ALS) EMS unit

Exclusion criteria

  • Resuscitation declined by patient's relatives
  • Cardiac arrest occurring in unsafe or inappropriate locations for EMS intervention
  • EMS-witnessed cardiac arrest
  • Inability of bystander to communicate in Thai
  • Cases where ALS unit is not directly dispatched to the scene

Treatment and study plan

Telemedicine-Assisted CPR (TA-CPR)

Behavioral

Participants receive dispatcher or EMS-guided cardiopulmonary resuscitation (CPR) with an initial audio-based instruction followed by real-time video communication when feasible. Video guidance is implemented based on device capability, connectivity, and availability of an additional bystander to assist with video transmission. If video is not feasible, CPR instructions continue via audio.

Dispatcher-Assisted CPR (DA-CPR)

Behavioral

Participants receive conventional dispatcher-assisted CPR instructions delivered exclusively via audio (telephone communication) without the use of video support.

Primary outcomes

  1. Bystander CPR rate

    Time frame: From enrollment to the end of resuscitation at 1 day

    Proportion of patients with suspected out-of-hospital cardiac arrest who receive cardiopulmonary resuscitation from a bystander prior to EMS arrival

Secondary outcomes

  1. Ongoing bystander CPR at EMS arrival

    Time frame: From enrollment to the end of resuscitation at 1 day

    Proportion of patients receiving continuous chest compressions by bystanders at the time EMS arrives

  2. Protocol compliance

    Time frame: From enrollment to the audit protocol at 4 weeks

    Proportion of cases in which EMS personnel adhere to all required steps of the assigned CPR instruction protocol (including successful video use in TA-CPR when applicable)

  3. Return of spontaneous circulation (ROSC) at emergency department

    Time frame: From enrollment to the end of resuscitation at 1 day

    Return of spontaneous circulation (ROSC) at emergency department

  4. Survival to hospital admission

    Time frame: During hospitalization (assessed up to 5 days)

  5. Survival to hospital discharge

    Time frame: During hospitalization (assessed up to 24 weeks)

Sponsors and collaborators

Lead sponsor

Siriraj Hospital

Other

Registry information

Acronym: TACTIC

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Apr 22, 2026
Registry last updated
Apr 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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