Telehealth Exercise Program Evaluating Fatigue and Physical Function in Rural Cancer Survivors

The Functional Assessment of Chronic Illness Therapy - Fatigue scale (FACIT-Fatigue) is a common standardized measure of cancer-related fatigue. It contains 13 items with total score ranging from 0 to 52, with higher scores indicating less fatigue.

The Functional Assessment of Chronic Illness Therapy - Fatigue scale (FACIT-Fatigue) is a common standardized measure of cancer-related fatigue. It contains 13 items with total score ranging from 0 to 52, with higher scores indicating less fatigue.

The Functional Assessment of Cancer Treatment - General scale (FACTG-G) is a common standardized measure of quality of life in cancer survivors. It contains 27 items with total score ranging from 0 to 108, with higher scores indicating better quality of life.

The Functional Assessment of Chronic Illness Therapy - Fatigue scale (FACIT-Fatigue) is a common standardized measure of cancer-related fatigue. It contains 13 items with total score ranging from 0 to 52, with higher scores indicating less fatigue.

Scores will be collected every two weeks during the intervention (or wait period) and change patterns established as the changes between adjacent timepoints.

The Functional Assessment of Cancer Treatment - General scale (FACTG-G) is a common standardized measure of quality of life in cancer survivors. It contains 27 items with total score ranging from 0 to 108, with higher scores indicating better quality of life.

The Hospital Anxiety and Depression Scale (HADS) is a common standardized measure of anxiety and depression in clinical populations. It contains 14 items yielding Anxiety and Depression scores. Scores range from 0 to 21, with higher scores indicating more anxiety or depressive symptoms.

The Hospital Anxiety and Depression Scale (HADS) is a common standardized measure of anxiety and depression in clinical populations. It contains 14 items yielding Anxiety and Depression scores. Scores range from 0 to 21, with higher scores indicating more anxiety or depressive symptoms.

The European Organisation for Research and Treatment of Cancer Group Quality of Life Questionnaire Fatigue 12 (EORTC QLQ-FA12) is a recently developed measure of cancer-related fatigue with multiple subscales (physical fatigue, emotional fatigue, and cognitive fatigue). It contains 12 items, with scores ranging from 0 to 100, and higher scores indicating higher fatigue symptoms.

The European Organisation for Research and Treatment of Cancer Group Quality of Life Questionnaire Fatigue 12 (EORTC QLQ-FA12) is a recently developed measure of cancer-related fatigue with multiple subscales (physical fatigue, emotional fatigue, and cognitive fatigue). It contains 12 items, with scores ranging from 0 to 100, and higher scores indicating higher fatigue symptoms.

The Two-Minute Step Test (2MST) is a submaximal test of aerobic capacity. Participants step in place for two minutes, raining each knee to a pre-specified height. Final measure is number of steps performed, with more steps indicating higher aerobic capacity.

The Chair Stand Test (CS) is an assessment of lower extremity function and muscular strength. Participants move from a seated position to standing and back as many times as possible in 30 s. Final measure is number of completed stands, with more stands indicating higher muscular strength and function.

Gait Speed (GS) is a common clinical measure of physical function. Participants are timed while walking at a 'usual' pace for 4 m. Final measure is m/s, with faster speeds indicating higher function.

The Timed Up and Go test (TUG) is a common clinical measure of physical function. Participants are timed while standing from a chair, walking 3 m, turning around, and returning to sit in the chair. Final measure is time to perform, with lower times indicating higher function.

Single Leg Balance (SLB) is a common clinical measure of balance and physical function. Participants are timed while standing on one leg with no external support (for up to 30 s). Final measure is time able to balance, with higher times indicating higher function.

Daily physical activity will be assessed for a 7-day period and calculated as average steps/day. This will be collected with a study provided commercial activity tracker.

Sleep time, assessed as time in bed at night, will be assessed over a 7-day period and averaged. This will be measured with a study provided commercial fitness tracker.

Fatty acid oxidation will be calculated as the ratio of medium- to long-chain acylcarnitines in metabolomic and lipidomic data acquired from high-throughput liquid chromatography-mass spectrometry. Samples are collected remotely as dried blood spots and mailed to the primary study site.

This measure is optional and performed at a participating study site. Small blood samples are collected before, after, and 30 min after a standard 36 min moderate intensity treadmill walking session. Dynamic metabolic profiles will be investigated by comparing analyses from the different timepoints (e.g. before-to-after exercise, recovery from after-to-30 minutes after exercise, etc.), using metabolomic and lipidomic data acquired from the collected samples via high-throughput liquid chromatography-mass spectrometry.

This measure is optional, performed during assessments at a participating study site. Body composition is measured while participants sit in a small, closed chamber for approximately two minutes, via air displacement plethysmography. The measure is presented as percent fat mass and percent lean mass.

The Functional Assessment of Cancer Treatment - General scale (FACTG-G) is a common standardized measure of quality of life in cancer survivors. It contains 27 items with total score ranging from 0 to 108, with higher scores indicating better quality of life.

Scores will be collected every two weeks during the intervention (or wait period) and change patterns established as the changes between adjacent timepoints.

The Hospital Anxiety and Depression Scale (HADS) is a common standardized measure of anxiety and depression in clinical populations. It contains 14 items yielding Anxiety and Depression scores. Scores range from 0 to 21, with higher scores indicating more anxiety or depressive symptoms.

Scores will be collected every two weeks during the intervention (or wait period) and change patterns established as the changes between adjacent timepoints.

The European Organisation for Research and Treatment of Cancer Group Quality of Life Questionnaire Fatigue 12 (EORTC QLQ-FA12) is a recently developed measure of cancer-related fatigue with multiple subscales (physical fatigue, emotional fatigue, and cognitive fatigue). It contains 12 items, with scores ranging from 0 to 100, and higher scores indicating higher fatigue symptoms.

Scores will be collected every two weeks during the intervention (or wait period) and change patterns established as the changes between adjacent timepoints.

The Two-Minute Step Test (2MST) is a submaximal test of aerobic capacity. Participants step in place for two minutes, raining each knee to a pre-specified height. Final measure is number of steps performed, with more steps indicating higher aerobic capacity.

Measure will be collected every two weeks during the intervention (or wait period) and change patterns established as the changes between adjacent timepoints.

The Chair Stand Test (CS) is an assessment of lower extremity function and muscular strength. Participants move from a seated position to standing and back as many times as possible in 30 s. Final measure is number of completed stands, with more stands indicating higher muscular strength and function.

Measure will be collected every two weeks during the intervention (or wait period) and change patterns established as the changes between adjacent timepoints.

Gait Speed (GS) is a common clinical measure of physical function. Participants are timed while walking at a 'usual' pace for 4 m. Final measure is m/s, with faster speeds indicating higher function.

Measure will be collected every two weeks during the intervention (or wait period) and change patterns established as the changes between adjacent timepoints.

The Timed Up and Go test (TUG) is a common clinical measure of physical function. Participants are timed while standing from a chair, walking 3 m, turning around, and returning to sit in the chair. Final measure is time to perform, with lower times indicating higher function.

Measure will be collected every two weeks during the intervention (or wait period) and change patterns established as the changes between adjacent timepoints.

Single Leg Balance (SLB) is a common clinical measure of balance and physical function. Participants are timed while standing on one leg with no external support (for up to 30 s). Final measure is time able to balance, with higher times indicating higher function.

Measure will be collected every two weeks during the intervention (or wait period) and change patterns established as the changes between adjacent timepoints.

Fatty acid oxidation will be calculated as the ratio of medium- to long-chain acylcarnitines in metabolomic and lipidomic data acquired from high-throughput liquid chromatography-mass spectrometry. Samples are collected remotely as dried blood spots and mailed to the primary study site.

Measure will be collected every two weeks during the intervention (or wait period) and change patterns established as the changes between adjacent timepoints.