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Completed

NCT Number: NCT02925572

Teenagers: Impact of Eccentric eXercise Training on Overweight and Obesity

Nowadays, eccentric exercise can be realized in a dynamic way with an ergocycle which permits eccentric (ECC) lower limbs contractions at a defined power output. With this type of ergometer, O2 consumption (VO2) in ECC is three fold lower than in concentric (CON) for the same power output. Consequently, ECC program could be used in chronic disorders with limited capacities, such as obesity.

The investigators hypothesis that an eccentric training program, as it will induce higher mechanical constraints, would improve body composition, especially by reducing fat mass. This effect could be explained by an increased rest energy expenditure and a better improvement in biological parameters (particularly lipid profile and insulin-resistance) after ECC training (versus CON training).

This study aims to compare the modification of fat mass after an ECC program versus a CON program at the same VO2.. The secondary goal is to assess the physiological mechanisms involved in the modification of body composition.

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Key information

Conditions

Adolescents (12 to 17 Years Old) Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Obese (BMI>90th Percentile) Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Pediatric Obesity Signs and Symptoms

Age range

12 year–17 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU Clermont-Ferrand

Clermont-Ferrand, 63003, France

About this study

40 obese adolescents will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2 weeks) to avoid the secondary muscular effects of high intensity eccentric exercise. The training program will last 12 weeks for the two groups. Before and after, each subjects will participate to the following measurements: total and segmental body composition (DXA), aerobic capacities (maximal incremental exercise test, VO2max), muscular lower limbs strength (isometric and isokinetic dynamometer), rest energy expenditure (indirect calorimetry), biological parameters (lipid profile, insulin-resistance), physical activity (actimetry), food intakes and quality of life (questionnaires).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adolescent (12 to 17 years old)
  • BMI>90th percentile
  • Post puberty (Tanner 3 to 5)
  • Inactive (<10 METS/h/week)
  • No other chronic disease (cardio pulmonary, osteo articulary or muscular diseases), no surgery during the last 3 months, no genetic obesity and no contraindication to physical activity

Exclusion criteria

-

Treatment and study plan

Cycling exercises

Other

All measurements are performed before and after the training program (12 weeks)

Primary outcomes

  1. change in total body fat mass (Dual X ray Absorptiometry)

    Time frame: before and after the 12 weeks training program

Secondary outcomes

  1. aerobic capacities (VO2max)

    Time frame: before and after the 12 weeks training program

  2. isometric muscular lower limbs strength

    Time frame: before and after the 12 weeks training program

  3. isokinetic muscular lower limbs strength

    Time frame: before and after the 12 weeks training program

  4. rest energy expenditure (indirect calorimetry)

    Time frame: before and after the 12 weeks training program

  5. biological parameters (plasma lipid profile and insulin-resistance )

    Time frame: before and after the 12 weeks training program

  6. physical activity (actimetry and questionnaires)

    Time frame: before and after the 12 weeks training program

  7. food intakes (measurements and questionnaires)

    Time frame: before and after the 12 weeks training program

  8. quality of life (questionnaires)

    Time frame: before and after the 12 weeks training program

  9. segmental body composition (segmental fat and fat free mass, Dual X-ray Absorptiometry)

    Time frame: before and after the 12 weeks training program

Sponsors and collaborators

Lead sponsor

University Hospital, Clermont-Ferrand

Other

Collaborators

  • ONAPS : Observatoire National de l'Activité Physique et de la Sédentarité

Registry information

Official study title

Impact of Muscular Training Program on Body Composition of Overweight and Obese Teenagers: classi201c Cycling Exercise in Concentric Versus Eccentric

Acronym: TEXTOO

Important dates

Study start
2017
Primary completion
2019
Study completion
2020
First posted
Oct 6, 2016
Registry last updated
Aug 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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