Technical Evaluation of Cardiovascular Magnetic Resonance Imaging and Spectroscopy

Magnetic resonance imaging (MRI) and spectroscopy are diagnostic tools that create high quality images of the human body without the use of X-ray (radiation). MRI uses different levels of magnetic fields to create images of the body and organs. Occasionally, researchers will give patients undergoing a MRI an injection of a contrast substance. The contrast substance works by brightening areas of the magnetic resonance image.

In this study researchers plan to use magnetic resonance imaging with contrast substances and exercise on normal volunteers in order to evaluate different aspects of its performance. Information gathered from this study may be used to develop more specific research studies involving MRI....

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Key information

Conditions

Cardiovascular Disease Cardiovascular Diseases Healthy

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Suburban Hospital

Bethesda, Maryland, 20814, United States

About this study

Technical evaluation of magnetic resonance imaging and spectroscopy will be performed on normal volunteers. These studies will be conducted in the NIH MRI systems located in Suburban Hospital in Bethesda, Maryland. These studies may involve the intravenous administration of commercially available MR contrast media and exercise. The results will be used to evaluate the performance of various pulse sequences, gradient coils, and RF coils on human subjects and will provide essential ground work for specific patient protocols.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

INCLUSION CRITERIA:

Any normal volunteer above the age 18 who is capable of giving informed consent will be included.

Exclusion criteria

A subject will be excluded if he/she has a contradiction to MR scanning.

Brain aneurysm clip
Implanted neural stimulator
Implanted cardiac pacemaker implanted defibrillator
Cochlear implant
Ocular foreign body (e.g. metal shavings)
Insulin pump
Pregnant women (when uncertain, subjects will undergo urine or blood testing).
Kidney
Paralyzed hemidiaphragm
Morbid obesity
Claustrophobia
Any condition in the PI's judgement which present unncessary risk

Exclusion criteria

FOR GADOLINIUM ENHANCED STUDIES:

Lactating women
Subjects with hemoglobinopathies
Asthma
Renal or hepatic disease

Subjects will be excluded if it is deemed that they have a condition that would preclude their use for technical development (e.g. paralyzed hemidiaphragm, morbid obesity, claustrophobia etc.) or present unnecessary risk (e.g. pregnancy, surgery of uncertain type, etc.).

Lactating women and subjects with hemoglobinopathies, asthma, or renal or hepatic disease will be excluded from studies involving the adminstration of contrast agents.

Sponsors and collaborators

Lead sponsor

National Heart, Lung, and Blood Institute (NHLBI)

Nih

Registry information

Important dates

Study start: 1999
Primary completion: 2009
Study completion: 2009
First posted: Nov 4, 1999
Registry last updated: Jul 2, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed