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NCT Number: NCT06843213

Teaching Health Resilience in a Hospital Setting: A Peer-led Intervention

The purpose of the study is to develop an acceptable, feasible, and effective peer-led bundle of health resilience and promotion services to be delivered in the hospital setting, called the THRIVE intervention.

The main question it aims to answer is: Will participants receiving the THRIVE intervention have a reduced risk of self-reported non-fatal overdoses OR skin/soft tissue infections compared to participants receiving enhanced usual care?

Researchers will compare the THRIVE model to enhanced usual care to see if the THRIVE model helps participants reduce their number of self-reported non-fatal overdoses OR skin/soft tissue infections.

Intervention participants will:

* Receive one in-person session from a peer support specialist while in the hospital * Receive weekly text messages from the peer support specialist for a 12-week period * Receive monthly, multiple-choice assessments via text message at Month 1, 2, 3, 4, 5, and 6 * Complete a baseline, 3-month, and 6-month assessment with Research Assistants

Enhanced usual care participants will:

* Receive a handout with health resilience education and resources in their local area * Receive monthly, multiple-choice assessments via text message at Month 1, 2, 3, 4, 5, and 6 * Complete a baseline, 3-month, and 6-month assessment with Research Assistants

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Key information

Conditions

Opioid Use Disorder Behavior Chemically-Induced Disorders Harm Reduction Health Promotion Mental Disorders Narcotic-Related Disorders Opioid-Related Disorders Substance-Related Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

UPMC Mercy Hospital, Pittsburgh, Pennsylvania, United States

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants who are: a) admitted to University of Pittsburgh Medical Center (UPMC) Shadyside Hospital, UPMC Presbyterian-Montefiore Hospital, UPMC Mercy Hospital for inpatient or observation status, or b) seen in the Emergency Department setting at UPMC Presbyterian-Montefiore Hospital and UPMC Mercy Hospital.
  • Participants must have a current diagnosis of Opioid Use Disorder based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) diagnostic criteria.
  • Participants must be at least 18 years of age on day of admission.
  • Participants must be able to speak and read English.

Exclusion criteria

  • Participants diagnosed with dementia and/or cognitive impairments.
  • Participants with acute psychiatric complications, such as schizophrenia with acute psychosis, acute mania, or suicidal ideation (which may impact the ability of a participant to consent and actively participate in treatment).
  • Participants who are pregnant or lactating at onset of study.
  • Participants who cannot read or speak English.

Treatment and study plan

Peer Intervention

Behavioral

Participants will receive one peer-led, in-person session boosted by weekly text messages over a 12-week period.

Enhanced usual care

Other

Participants will receive a handout that includes health resilience education and resources in their local area as part of enhanced usual care.

Primary outcomes

  1. Effectiveness of the THRIVE intervention compared to enhanced usual care (EUC) at lowering the incidence of non-fatal overdoses OR skin and soft tissue infections

    Time frame: Baseline to 6 months

    Cumulative incidence of non-fatal overdose OR skin and soft tissue infection

Secondary outcomes

  1. Effectiveness of the THRIVE intervention compared to EUC at lowering the incidence of non-fatal overdoses

    Time frame: Baseline to 6 months

    Cumulative incidence of non-fatal overdose

  2. Effectiveness of the THRIVE intervention compared to EUC at lowering the incidence of skin and soft tissue infections

    Time frame: Baseline to 6 months

    Cumulative incidence of skin and soft tissue infection

Other outcomes

  1. Effectiveness of the THRIVE intervention on change in higher risk infection behaviors (characterized by BIRSI score) compared to EUC

    Time frame: Baseline to 6 months

    Change in higher risk infection behaviors measured as the total score on the BIRSI

  2. Effectiveness of the THRIVE intervention on change in health resilience adoption compared to EUC (a)

    Time frame: Baseline to 6 months

    (a) Change in the proportion of participants who self-report naloxone use in past 30 days to reverse another person's overdose

  3. Effectiveness of the THRIVE intervention on change in health resilience adoption compared to EUC (b)

    Time frame: Baseline to 6 months

    (b) Change in the proportion of participants who self-report currently carrying naloxone

  4. Effectiveness of the THRIVE intervention on change in health resilience adoption compared to EUC (c)

    Time frame: Baseline to 6 months

    (c) Change in the proportion of participants who self-report using at least one drug checking strategy in the past 30 days

  5. Effectiveness of the THRIVE intervention on health resilience access compared to EUC (a)

    Time frame: Baseline to 6 months

    (a) Change in the proportion of participants who self-report having received at least one of: naloxone, syringes, or new or unused pipes in past 30 days

  6. Effectiveness of the THRIVE intervention on health resilience access compared to EUC (b)

    Time frame: Baseline to 6 months

    (b) Change in the proportion of participants who self-report visiting a syringe services program in past 30 days

  7. Effectiveness of the THRIVE intervention on health resilience access compared to EUC (c)

    Time frame: Baseline to 6 months

    (c) Change in the proportion of participants who self-report receiving any health resilience services from a needle exchange facility in past 30 days

  8. Heterogeneity of treatment effect by race (Black versus white) in the THRIVE intervention arm

    Time frame: Baseline to 6 months

    Cumulative incidence of non-fatal overdose OR skin or soft tissue infection, by race (Black versus white)

Study contacts

Contact information is provided by the study sponsor or research team.

Research Program Coordinator

CONTACT

[email protected]

412-679-9848

Sponsors and collaborators

Lead sponsor

University of Pennsylvania

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)
  • University of Pittsburgh

Registry information

Official study title

Teaching Health Promotion and Resilience in Varied Environments: a Peer-led Intervention Following Hospital Discharge

Acronym: THRIVE

Important dates

Study start
2025
Primary completion
2028
Study completion
2028
First posted
Feb 24, 2025
Registry last updated
Feb 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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