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NCT Number: NCT07168031

tDCS of the Left dlPFC: Effects on Information Processing

This study investigates how a non-invasive form of brain stimulation, called transcranial direct current stimulation (tDCS), affects brain activity and information processing in younger and older adults. The stimulation uses a very weak electrical current applied through electrodes placed on the scalp. This method is safe and widely used in research to study brain function.

Participants will complete computer-based tasks while receiving either active brain stimulation or a placebo (sham) stimulation. The task is designed to engage specific mental processes so that the investigators can study how the brain responds under different conditions. Brain activity will be measured using magnetic resonance imaging (MRI), both while participants perform the tasks and while they are resting.

The study will compare healthy younger (ages 20-40) and older (ages 60-80) adults to explore whether age influences how the brain responds to stimulation. By examining patterns of brain activation and connectivity, the investigators aim to better understand how tDCS can modulate cognitive processing across the adult lifespan.

The hypothesis is that applying tDCS to the left dorsolateral prefrontal cortex will change patterns of brain activity related to cognitive processing, and that these changes may differ between younger and older adults. This knowledge could help inform future research into brain stimulation techniques in different age groups.

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Key information

Conditions

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Bern, Department of Old Age Psychiatry and Psychotherapy

Bern, 3000, Switzerland

Location status: Recruiting

Location contact

Jessica Peter, Prof.

CONTACT

[email protected]

+41 58 630 89 03

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy younger adults (ages 20-40) or healthy older adults (ages 60-80)
  • Normal or corrected-to-normal vision and hearing
  • Right-handed (for consistency in brain stimulation)
  • Able to give written informed consent and comply with study procedures

Exclusion criteria

  • History of neurological or psychiatric disorders
  • Current use of medications that affect the central nervous system
  • Metal implants, pacemakers, or other contraindications for MRI or tDCS
  • History of seizures or epilepsy
  • Pregnancy
  • Participation in another brain stimulation study within the last 3 months
  • Any condition judged by investigators to interfere with safe participation

Treatment and study plan

Active Transcranial Direct Current Stimulation (tDCS)

Device

High definition tDCS will be applied, using a Soterix Medical device and 4x1 ring electrodes. A centre ring electrode overlying the target cortical region (left dlPFC at position F3 according to the 10-20 system) will be surrounded by four return electrodes (position F1, FC3, F5, and AF3).

Sham Transcranial Direct Current Stimulation (tDCS)

Device

The same setup and device as in the active tDCS group will be used, but in this case stimulation will be turned off after a ramp-up phase of 30 seconds. This mimics the same sensory feeling as active tDCS.

Primary outcomes

  1. Task Accuracy

    Time frame: During the intervention

    Accuracy in responses during an information processing task, measured as the proportion of correct responses.

  2. Task-Related Brain Activation

    Time frame: During the intervention

    Changes in blood-oxygen-level-dependent (BOLD) signal during the information processing task, measured using fMRI.

  3. Resting-State Functional Connectivity

    Time frame: Immediately before and after the intervention

    Changes in functional connectivity between brain regions before and after stimulation, measured using resting-state fMRI.

Secondary outcomes

  1. Task Reaction Time

    Time frame: During the intervention

    Time in milliseconds between stimulus presentation and participant response during the information processing task.

Study contacts

Contact information is provided by the study sponsor or research team.

Sarah Godehardt

CONTACT

[email protected]

+41 58 630 89 03

Sponsors and collaborators

Lead sponsor

University of Bern

Other

Registry information

Official study title

Neural and Age-Related Effects of Transcranial Direct Current Stimulation of the Left dlPFC During Information Processing

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Sep 11, 2025
Registry last updated
Sep 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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