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NCT Number: NCT06830174

tDCS for Laryngeal Dystonia

This project will apply transcranial direct current stimulation (tDCS) to multiple brain areas to evaluate the effects as a potential treatment for laryngeal dystonia (formerly spasmodic dysphonia).

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Key information

Conditions

Laryngeal Dystonia Dysphonia Laryngeal Diseases Nervous System Diseases Neurologic Manifestations Otorhinolaryngologic Diseases Pathological Conditions, Signs and Symptoms Respiratory Tract Diseases Signs and Symptoms Voice Disorders

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Yale University

New Haven, Connecticut, 06511, United States

Location status: Recruiting

Location contact

Nabin Koirala, PhD

CONTACT

[email protected]

203-785-2527

About this study

Baseline neuroimaging data will be acquired from all participants via MRI, EEG. Each participant will be seen for multiple testing sessions over a five day period. LD participants will undergo the neuromodulation (HD-tDCS Stimulation) for twenty minutes while engaged in watching videos/movies or performing a word production task.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants must be clinically evaluated for the diagnosis of LD or have the proof of LD diagnosis. (Not applicable for control participants)
  • No other known or history of speech, voice disorder other than LD.
  • Provision of signed and dated informed consent form.
  • Stated willingness to comply with all study procedures and availability for the duration of the study
  • Must not be pregnant.

Exclusion criteria

  • All individuals who do not meet the above mentioned criteria are excluded from the study.
  • Subjects with a history of epilepsy or depression or is claustrophobic.

Treatment and study plan

Starstim system

Device

Transcranial direct current stimulation (tDCS)

Primary outcomes

  1. Change in Cepstral peak prominence (CPP)

    Time frame: daily on Day 1-Day 5

    Cepstral peak prominence (CPP) as a robust objective measure of voice quality in the active, sham and no stimulation conditions.

  2. Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V)

    Time frame: daily on Day 1-Day 5

    Its primary purpose is to describe the severity of auditory-perceptual attributes of a voice problem, in a way that can be communicated among clinicians

Study contacts

Contact information is provided by the study sponsor or research team.

Nabin Koirala, PhD

CONTACT

[email protected]

203 7852527

Sponsors and collaborators

Lead sponsor

Yale University

Other

Collaborators

  • National Spasmodic Dysphonia Association

Registry information

Official study title

Network Targeted Transcranial Direct Current Stimulation (tDCS) as a Treatment for Laryngeal Dystonia (LD)

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Feb 17, 2025
Registry last updated
Feb 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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