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Completed

NCT Number: NCT05471947

TCA 15% Chemical Peel for Improvement in Hand Lentigines

This study will evaluate the efficacy of the a 15% trichloroacetic acid + 3% glycolic acid peel combination for treatment of lentigines on the hands. This peel combination is sold over the counter. Patients will receive 3 treatments (spaced 4 weeks).

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Key information

Conditions

Photoaging Hyperpigmentation Lentigo Melanosis Pigmentation Disorders Skin Diseases Skin and Connective Tissue Diseases

Age range

22 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Main Line Center for Laser Surgery

Ardmore, Pennsylvania, 19003, United States

About this study

This clinical investigation is a prospective study consisting of a screening visit, 3 treatment visits, and 1 follow-up visit. Baseline and post-treatment photos will be graded and compared.

A total of 20 patients will be recruited. Following informed consent and screening, subjects' dorsal hands will be photographed.

Patients will receive 3 treatments with the 15% TCA + 3% glycolic acid peel every 4-6 weeks on the dorsal hands. Post-treatment, patients will be instructed to apply Aquaphor to the treated area twice daily for 5 days. Patients' hands will be photographed at each visit.

Four to six weeks after their final treatment, subjects will return for photography.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age >21
  • No laser, chemical peel, neuromodulator, filler treatment to the hands in >3 months
  • At least 5 lentigines on each hand

Exclusion criteria

  • Pregnancy
  • Breastfeeding
  • Allergy to trichloroacetic acid
  • Allergy to glycolic acid
  • Open wounds on treatment area (hands)
  • Active inflammatory disease on treatment area such as atopic dermatitis, psoriasis, dermatomyositis

Treatment and study plan

15% Trichloroacetic acid + 3% glycolic acid

Drug

Treatment of the hand with an over-the-counter chemical peel containing 15% trichloroacetic acid + 3% glycolic acid

Other names: 15% TCA + 3% GA

Primary outcomes

  1. Improvement in hand lentigines on a 5-point scale

    Time frame: 4-6 weeks after last treatment

    Photos will be graded on a 5 point scale (0=no change, 1=1-25% change, 2=26-50% change, 3=51-75% change, 4=76-100% change)

Secondary outcomes

  1. Improvement in hand lentigines using the Global Aesthetic Improvement Scale

    Time frame: 4-6 weeks after last treatment

    The GAIS is a validated scale assessing overall change after aesthetic procedures

Sponsors and collaborators

Lead sponsor

Main Line Center for Laser Surgery

Other

Registry information

Official study title

Use of TCA 15% + 3% Glycolic Acid Chemical Peel for Improvement in Hand Lentigines

Important dates

Study start
2023
Primary completion
2023
Study completion
2024
First posted
Jul 25, 2022
Registry last updated
Mar 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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