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Completed

NCT Number: NCT06635369

Taurine in Periodontitis and Aging

Aging leads to a decline in physiological functions and increases the risk of chronic diseases. Periodontitis is a chronic inflammatory disease that causes progressive destruction of the tissues supporting the teeth. Taurine, an amino acid with anti-inflammatory and antioxidant effects, might impact both periodontitis and aging. This study investigated taurine, SIRT1, and TNF-α levels in saliva and blood of 66 healthy people in different age groups, with or without periodontal disease. The findings showed that young people with healthy periodontal status had higher levels of taurine and SIRT1 compared to others. TNF-α, a marker of inflammation, was linked to the severity of periodontitis and may help identifying it in younger individuals. Overall, higher TNF-α levels are associated with periodontal inflammation, while taurine levels decrease with age-related inflammation.

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Key information

Conditions

Peridontal Disease Aging Inflammation Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Periodontitis Stomatognathic Diseases

Age range

26 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Istanbul Medipol University

Istanbul, Unkapani, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Exclusion criteria

  • ages 18-25 or 45-64
  • use of antibiotics, anti-inflammatory drugs, immunosuppressants, beta-blockers, calcium channel blockers, or anticoagulants within the last 6 months
  • presence of diabetes, rheumatoid arthritis, or other systemic conditions such as cardiovascular, renal, hepatic, and neurodegenerative disorders
  • pregnancy or lactation
  • alcoholism
  • smoking
  • nonsurgical periodontal treatment in the past 6 months or surgical treatment in the past 12 months
  • having less than 20 natural teeth, excluding third molars
  • use of orthodontic appliances

Treatment and study plan

Periodontal Indices

Diagnostic Test

Saliva, serum and periodontal indexes were obtained from patients

Other names: Salivary Flow Rate, TNF-α Levels, SIRT1 Levels, Taurine Levels

Primary outcomes

  1. Taurine

    Time frame: 12 Weeks

    Taurine levels in saliva and serum were measured

  2. SIRT1

    Time frame: 12 Weeks

    SIRT1 levels in saliva and serum were measured

  3. TNF-α

    Time frame: 12 Weeks

    TNF-α levels in saliva and serum were measured

Sponsors and collaborators

Lead sponsor

Istanbul Medipol University Hospital

Other

Registry information

Official study title

The Role of Taurine in Periodontitis and Aging: a Preliminary Study

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Oct 10, 2024
Registry last updated
Oct 10, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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