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OpenTrials
Completed

NCT Number: NCT05149716

Taurine as a Possible Anti-aging Therapy?

Among the strategies that can improve the body's ability to counteract oxidative stress, the use of nutritional antioxidants has been investigated. Taurine is a "semi-essential" amino acid, also called a nitrogen compound, which has been used as an effective antioxidant due to its ability to neutralize hypochlorous acid, an extremely toxic oxidant produced by leukocytes in the inflammatory process in humans.

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Key information

Conditions

Oxidative Stress

Age range

55 year–70 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Escola de Educação Física e Esporte de Ribeirão Preto

Ribeirão Preto, São Paulo, 14040-907, Brazil

About this study

Objective: To evaluate the oxidative parameters of women aged 55 to 70 years after 16 weeks of taurine supplementation.

Methods: Twenty-four women age 55 to 70 will be randomly assigned to two groups: control group (GC), supplemented with placebo (1.5 g of starch); and taurine group (GTAU), supplemented with taurine (1.5 g), for 16 weeks. Anthropometry, functional capacity test, taurine, and levels of oxidative stress markers will be determined in pre and post intervention plasma samples. Food consumption will be assessed before, during, and after the intervention. The results will be analyzed by an ANOVA two-way repeated measures mixed model, with the Sidak post hoc (p < 0.05).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Had being aged 55-70 years;
  • Female;
  • Post-menopausal;
  • Sedentary (not practicing physical exercise for at least 6 months).

Exclusion criteria

  • Chronic kidney diseases;
  • Infectious contagious diseases;
  • Coronary heart disease;
  • Smokers
  • Alcoholics.

Treatment and study plan

Taurine

Dietary Supplement

Taurine supplementation in capsules of 500 grams of taurine powder, total dosage: 1.5 gram/day

Other names: Taurine supplementation in capsules of 500 grams of taurine powder, total dosage: 1.5 grams/day

Placebo

Dietary Supplement

Placebo supplementation in capsules of 500 grams of starch powder, total dosage: 1.5 gram/day

Primary outcomes

  1. Change from baseline in blood oxidative stress marker measurement - Superoxide Dismutase (SOD).

    Time frame: sixteen weeks

    The superoxide dismutase (SOD) activity in erythrocytes was evaluated by the spectrophotometric method, and were calculated at 16 weeks in comparision to the baseline.

  2. Change from baseline in blood oxidative stress marker measurement - Glutathione reductase (GR).

    Time frame: sixteen weeks

    Glutathione reductase (GR) activity was determined by the spectrophotometric method at 37 ºC/340nm after the oxidation of NADPH in the presence of oxidized glutathione, and were calculated at 16 weeks in comparision to the baseline.

  3. Change from baseline in blood oxidative stress marker measurement - Malondialdehyde (MDA).

    Time frame: sixteen weeks

    The malondialdehyde (MDA) were calculated at 16 weeks in comparision to the baseline.

Sponsors and collaborators

Lead sponsor

University of Sao Paulo

Other

Collaborators

  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
  • Fundação de Amparo à Pesquisa do Estado de São Paulo

Registry information

Official study title

Taurine as a Possible Anti-aging Therapy? A Controlled Clinical Trial on Taurine Antioxidant Activity in Women Aged 55 to 70 Years

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Dec 8, 2021
Registry last updated
Dec 8, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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