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NCT Number: NCT02902198

Taste Physiology in Obese Volunteers Before and After Bariatric Surgery

The objective is to investigate neuro-anatomical correlates of gastrointestinal taste stimulation by means of functional MRI before and after bariatric surgery. Intragastric administration of glucose, monosodium glutamate, chloroquine and placebo is followed by functional brain MRI in obese humans before and 3 months after surgery.

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Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hopital Basel

Basel, Switzerland

Location status: Recruiting

Location contact

Bettina Wölnerhanssen, Dr

CONTACT

[email protected]

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • morbidly obese patients (BMI min 35kg/m2) scheduled for bariatric surgery
  • right handed

Exclusion criteria

  • cardiovascular disease
  • neurologic/psychiatric disorders

Treatment and study plan

Placebo

Dietary Supplement

Tap water 200ml

Glucose

Dietary Supplement

25g Glucose in 200ml tap water

Monosodium Glutamate

Dietary Supplement

1g monosodium glutamate in 200ml tap water

Quinine

Dietary Supplement

17mg quinine in 200ml tap water

Primary outcomes

  1. Effect of tastants on cerebral blood flow measured by functional brain MRI

    Time frame: changes from baseline to one hour after treatment

Secondary outcomes

  1. Effect of tastants plasma glucagon-like peptide (GLP-1) concentrations

    Time frame: changes from baseline to one hour after treatment

  2. Effect of tastants plasma ghrelin concentrations

    Time frame: changes from baseline to one hour after treatment

Study contacts

Contact information is provided by the study sponsor or research team.

Bettina Wölnerhanssen, Dr

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

University Hospital, Basel, Switzerland

Other

Registry information

Important dates

Study start
2014
Primary completion
2026
Study completion
2027
First posted
Sep 15, 2016
Registry last updated
Apr 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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