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NCT Number: NCT06632626

Task-oriented Training on Hand Function in Taxanes-induced Peripheral Neuropathy

Chemotherapy based on taxanes is commonly used to treat breast cancer. However, chemotherapy-induced peripheral neuropathy (CIPN), a side effect of taxanes, impairs a patient's grip strength, hand dexterity, and upper extremity function which affects quality of life (QOL).

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Key information

Conditions

Peripheral Neuropathy Breast Diseases Breast Neoplasms Chemotherapy Effect Hand Function Neoplasms Neoplasms by Site Nervous System Diseases Neuromuscular Diseases Peripheral Nervous System Diseases Skin Diseases Skin and Connective Tissue Diseases

Age range

35 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

faculty of physical therapy, Cairo university

Giza, 11432, Egypt

About this study

Task-oriented training, a type of exercise where exercises are organized into tasks, concentrates on enhancing particular functional abilities through useful, goal-directed activities. So, the purpose of the study to explore the effectiveness of task-oriented training (TOT) on grip strength, hand dexterity and upper extremity function in patients with taxanes-induced peripheral neuropathy.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients were females only.
  • Their ages range from 35 to 65.
  • All patients suffered from CIPN after using taxanes (anti-cancer agent causing neurotoxic effect).
  • Diagnosis of CIPN was determined based on symptom history or the presence of stocking glove pattern "distal dysesthesias, pain and numbness" beginning after taxanes intake.
  • All patients enrolled to the study had their informed consent.
  • Patients suffer from affected brachial plexus.

Exclusion criteria

  • Patients had pain or numbness in the upper extremity due to other reasons like trauma (fracture), CNS diseases (cerebral infarction), other diseases with neurological symptoms like (diabetes, rheumatoid arthritis or cervical myelopathy).
  • Patients had bone, brain or spinal cord metastases.
  • Patients who had history of psychiatric disorders like: depression and schizophrenia or cognitive decline that may hinder them from active participation in the study.
  • Patients exhibited only acute neuropathy like in patients using oxaliplatin.

Exclusion criteria

  • Patients had pain or numbness in the upper extremity due to other reasons like trauma (fracture), CNS diseases (cerebral infarction), other diseases with neurological symptoms like (diabetes, rheumatoid arthritis or cervical myelopathy).
  • Patients had bone, brain or spinal cord metastases.
  • Patients who had history of psychiatric disorders like: depression and schizophrenia or cognitive decline that may hinder them from active participation in the study.
  • Patients exhibited only acute neuropathy like in patients using oxaliplatin

Treatment and study plan

Task oriented training exercises

Other

Task oriented training is a type of exercises in form of tasks using papers, pens, scissors, clips, coins, screws and clay

Traditional Physical therapy

Other

Traditional physical therapy inform of mobilization, strengthening exercises of hand and streching exercises.

Primary outcomes

  1. Hand grip strength

    Time frame: At baseline and after four weeks of intervention.

    Hand grip strength (HGS) was measured in the dominant hand for each patient using The CAMRY dynamometer

  2. Hand dexterity

    Time frame: At baseline and after four weeks of intervention.

    The nine-hole peg test was used to assess the hand dexterity

  3. Hand function

    Time frame: At baseline and after four weeks of intervention.

    Each patient was asked to answer the questions of the six scales in the Arabic version of Michigan hand questionnaire (1- Overall hand function, 2-Activities of Daily Living, 3- Work performance, 4- Pain, 5- Aesthetics, and 6- Satisfaction with hand function)

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Task-oriented Training on Hand Function in Patients With Taxanes-induced Peripheral Neuropathy

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Oct 9, 2024
Registry last updated
Oct 18, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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