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Completed

NCT Number: NCT03381456

Task-dependent Operation of a Mechanism Intracortical Inhibition in Dystonia

Cortical excitability depends on inhibitory mechanisms efficiency among which long latency intracortical inhibition (LICI) can be studied by paired pulses transcranial magnetic stimulation (TMS). Some recent evidences suggest that LICI may be one of the mechanisms by which the motor comment is adapted to the ongoing motor task with LICI strength being dependent on task complexity. In writer cramp and musician cramp, two forms of dystonia, the cortical excitability is not correctly modulated in some complex gestures. the hypothesis is that this task dependent perturbation of excitability in writer cramp could be due to a lack of LICI efficiency.

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Key information

Conditions

Dystonia, Primary Central Nervous System Diseases Dystonic Disorders Movement Disorders Nervous System Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hôpital Roger Salengro, CHRU de Lille

Lille, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient with hand dystonia : writers cramp
  • Subject affiliated to social security regimen.

For healthy volunteers :

  • Healthy volunteer without neurological disorders based on sensorimotor examination.
  • Subject affiliated to social security regimen.

Exclusion criteria

  • Subject unable to receive informed consent (dementia).
  • Contraindication to Transcranial Magnetic Stimulation(TMS) (epilepsia, intracranial metalic foreign object, hearing device, cochlear implant).
  • Patient using a psychotrope treatment.
  • Patient under guardianship or curatorship.
  • Pregnant or nursing women.
  • Patient with a cardiac stimulator.

For healthy volunteers only :

  • Abnormal neurological evaluation based on sensorimotor examination or neurological history ( epilepsy, stroke ; brain or spinal cord surgery ; history of neurological disease affective sensitive and motor control)

Treatment and study plan

LICI

Other

Paired pulse TMS to measure LICI and late cortical disinhibition

Primary outcomes

  1. long-interval intracortical inhibition (LICI) level

    Time frame: Baseline

    Amount of inhibition at interstimulus intervals of between 50 to 300ms

Sponsors and collaborators

Lead sponsor

University Hospital, Lille

Other

Registry information

Acronym: LICIdystonie

Important dates

Study start
2015
Primary completion
2017
Study completion
2017
First posted
Dec 22, 2017
Registry last updated
Dec 22, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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