Task Control Circuit Targets for Obsessive Compulsive Behaviors in Children

Recruitment is complete. U.S. Department of Health and Human Services OHRP issued an FWA restriction on NYSPI research that included a pause of human subjects research as of June 23, 2023. This study will resume analysis of results from its two sites for results reporting after OHRP and the IRB has approved the resumption of research.

Obsessive-Compulsive Disorder (OCD) patient group

INCLUSION:

• Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) Diagnosis of OCD as the principal problem
• Not on psychotropic medication and not receiving current psychotherapy for OCD
• Written informed assent by the participants and consent by the parent
• Participants and a parent/guardian must be able to read and understand English

EXCLUSION

• DSM-5 current diagnosis of major depressive disorder, or substance/alcohol abuse
• DSM-5 lifetime diagnosis of psychotic disorder, bipolar disorder, eating disorder, pervasive developmental disorder, or substance/alcohol abuse
• Individuals who are currently receiving CBT, other forms of psychotherapy, or psychotropic medications (stable doses of stimulants or other types of ADHD medications - e.g. Guanfacine - are allowable for OCD subjects with comorbid attention deficit hyperactivity disorder following investigator review of medication; on day of study scan, subjects must be willing to refrain from taking medication until after scan is completed)
• Active suicidal ideation
• Females who are pregnant or nursing
• Major medical or neurological problems
• Presence of metallic device or dental braces
• Intelligence Quotient (IQ)<80
• A current or past diagnosis of pediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS)
• Individuals who are currently receiving CBT, other forms of psychotherapy, or psychotropic medications
• Individuals who have received a full course of CBT in the past
• A positive pregnancy test
• Positive urine screen for illicit drugs

Healthy controls

INCLUSION:

• Written informed assent by the participants and consent by the parent
• Participants and a parent/guardian must be able to read and understand English

EXCLUSION:

• Any current or lifetime psychiatric diagnosis
• Active suicidal ideation
• Females who are pregnant or nursing
• Major medical or neurological problems
• Presence of metallic device or dental braces
• IQ <80
• A current or past diagnosis of pediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS)
• A positive pregnancy test
• Positive urine screen for illicit drugs

Obsessive Compulsive Symptoms

INCLUSION:

• Presence of obsession(s) and/or compulsion(s) but no current diagnosis of OCD (i.e.,<1 hour/day, no more than mild interference or distress)
• Not on psychotropic medication and not receiving current psychotherapy for OCD
• Written informed assent by the participants and consent by the parent
• Participants and a parent/guardian must be able to read and understand English

EXCLUSION:

• DSM-5 current diagnosis of major depressive disorder, attention-deficit hyperactivity disorder, Tourette's/Tic Disorder, or substance/alcohol abuse
• DSM-5 lifetime diagnosis of psychotic disorder, bipolar disorder, eating disorder, pervasive developmental disorder, or substance/alcohol abuse
• Active suicidal ideation
• Females who are pregnant or nursing
• Major medical or neurological problems
• Presence of metallic device or dental braces
• IQ<80
• A current or past diagnosis of pediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS)
• Individuals who are currently receiving CBT, other forms of psychotherapy, or psychotropic medications
• Individuals who have received a full course of CBT in the past
• Positive urine screen for illicit drugs