Skip to main content
OpenTrials
Completed

NCT Number: NCT04066101

TAS1R1, TAS1R3, TLR2, TLR4, CA6 Gene Polymorphism on Dental Caries

The aim of this study is to examine the effects of TAS1R1, TAS1R3, TLR2, TLR4, CA6, gene polymorphism on caries risk in adults.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

High Caries Risk Low Caries Risk

Age range

25 year–44 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Recep Tayyip Erdogan University

Rize, 53000, Turkey (Türkiye)

About this study

To date, genes can be grouped into categories based on the factor influencing dental caries. The major candidate gene categories to date include enamel formation genes, immune response genes, genes related to saliva, and genes related to taste and dietary habits.

CA6 exists in the human saliva and has a critical role of buffering, immune response and taste.Toll-like receptors are expressed in the tongue gustatory papillae where they may initiate immune responses to pathogens.Genetic variations in the TAS1R1 and TAS1R3 for umami cause perception of these tastes differently.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adult be between 25 and 44 years old
  • subject has DMFT (Decayed, Missing, Filled, Permanent Tooth) ≥ 5, or, DMFT ≥14
  • same oral health, diet and socioeconomic status

Exclusion criteria

  • systemic or genetic disorders
  • orthodontic appliances
  • pregnant women

Treatment and study plan

high caries risk

Genetic

DNAs were obtained from epithelial cells in buccal mucosa and were extracted with Genomic DNA Isolation Kit Genotyping for a variant was carried out on a Roche Applied Science LightCycler® 480 (Roche Diagnostics GmbH, Mannheim, Germany) with real-time polymerase reaction of Taqman

Other names: DNA isolation, genotyping

caries activity

Other

Dental caries lesions of all patient scored as initial, moderate or advanced caries

Initial lesion; clinically detectable lesion Moderate; visible signs of enamel breakdown Advanced; enamel was fully cavitaed

Primary outcomes

  1. Past caries experience

    Time frame: 4 months

    Each tooth will be examined and recorded as decayed, missing, or filled (DMFT). Caries will be defined in accordance with the World Health Organization (WHO 1997) criteria.

Sponsors and collaborators

Lead sponsor

Recep Tayyip Erdogan University Training and Research Hospital

Other

Registry information

Official study title

Variants in Taste Genes on Caries Risk and Caries Activity Status

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Aug 26, 2019
Registry last updated
Apr 15, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.