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OpenTrials
Completed

NCT Number: NCT05219994

Targeting the Carotid Bodies to Reduce Disease Risk Along the Diabetes Continuum

Our overall goal is to advance our understanding of the contribution of the carotid body chemoreceptors in glucose regulation and the development of type 2 diabetes.

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Key information

Conditions

Type 2 Diabetes Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Missouri

Columbia, Missouri, 65211, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy,
  • type 2 diabetes
  • BMI 18-40 kg/m2,
  • non-pregnant,
  • non-breastfeeding,
  • non-nicotine users.

Exclusion criteria

  • cardiovascular disease including myocardial infarction, heart failure, coronary artery disease, stroke;
  • renal or hepatic diseases;
  • active cancer;
  • autoimmune diseases;
  • immunosuppressant therapy;
  • excessive alcohol consumption (>14 drinks/week);
  • current nicotine use;
  • foot ulcers;
  • diabetic neuropathy;
  • medication directly influencing sympathetic nervous system activity

Treatment and study plan

Hyperoxia Exposure

Other

2 hours of hyperoxia exposure during OGTT

Normoxia Exposure

Other

2 hours of normoxia exposure during OGTT

Primary outcomes

  1. Glucose change in response to OGTT

    Time frame: 2 hours post glucose ingestion

  2. Insulin change in response to OGTT

    Time frame: 2 hours post glucose ingestion

Sponsors and collaborators

Lead sponsor

University of Missouri-Columbia

Other

Registry information

Important dates

Study start
2020
Primary completion
2023
Study completion
2023
First posted
Feb 2, 2022
Registry last updated
Jul 27, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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