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OpenTrials
Recruiting

NCT Number: NCT06868927

Targeted Decision Making In Renal Cell Carcinoma Relying on a Radiogenomics Translational Platform

This project aims to provide an accurate strategy to guide the decision making relying on tumor biopsies using standard histology, immunohistochemistry (IHC), spatial transcriptomics, genomics combined with Magnetic Resonance Imaging (MRI) and radiomics. Moreover, the investigators will explore potential markers indicative of response to systemic agents or ablative therapy.

Recruiting

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Key information

Conditions

Renal Tumors Adenocarcinoma Carcinoma Carcinoma, Renal Cell Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Kidney Neoplasms Male Urogenital Diseases Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Urogenital Diseases Urogenital Neoplasms Urologic Diseases Urologic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Presence of a renal mass up to 4 cm
  • Adult > 18 years
  • Candidate to renal surgery
  • Informed consent signed

Exclusion criteria

  • Contraindication for MRI

Treatment and study plan

Primary outcomes

  1. accuracy of multiparametric preoperative MRI

    Time frame: At final pathological assessment , at least 1 month after surgery

    Detection of "Unfavourable outcome" is defined as the presence of at least one of the following pathological characteristics:

    • High grade tumor (G3 or G4)
    • Not-organ confined disease (pT3 and or pT4 and/or LNI)
    • Sarcomatoid features

Study contacts

Contact information is provided by the study sponsor or research team.

Umberto Capitanio

CONTACT

[email protected]

3492503788

Sponsors and collaborators

Lead sponsor

IRCCS San Raffaele

Other

Registry information

Acronym: TARGET-RCC

Important dates

Study start
2025
Primary completion
2029
Study completion
2029
First posted
Mar 11, 2025
Registry last updated
Mar 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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