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OpenTrials
Completed

NCT Number: NCT07420608

Targeted Ankle Proprioceptive Training Improves Balance, Gait, and Functional Mobility in Chronic Stroke Survivors

Stroke is a leading cause of long-term disability, with balance and gait deficits affecting >80% of survivors and increasing fall risk. Emerging evidence links ankle proprioceptive impairment-particularly inversion/eversion acuity-to these deficits, often bilateral and central in origin. Cross-sectional studies show strong associations, but causality, temporal progression, and intervention efficacy (especially in severe/non-ambulatory cases) remain unproven. This trial tests a targeted proprioceptive protocol against standard care.

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Key information

Conditions

Proprioceptive Disorders Balance; Distorted Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Neurologic Manifestations Pathological Conditions, Signs and Symptoms Sensation Disorders Signs and Symptoms Somatosensory Disorders Stroke Stroke Sequelae Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

IQRA National University

Swāt, Peshawar, Pakistan

About this study

Objectives: Primary: To evaluate the causal effect of 12-week targeted ankle proprioceptive training on weight-bearing ankle proprioception (AMEDA) in chronic stroke survivors.

Secondary: To assess effects on balance (Berg Balance Scale), gait speed (10m walk test), mobility (Timed Up and Go, Functional Ambulation Category), lower extremity motor function (Fugl-Meyer), and sustainability at 6-month follow-up. To describe longitudinal proprioceptive changes in a subsample from acute to chronic stages.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of chronic ischemic/hemorrhagic stroke (≥12 months post-stroke)
  • Moderate-to-severe lower extremity impairment (Fugl-Meyer LE ≤28 or NIHSS motor leg ≥2)
  • Documented ankle proprioceptive deficit (AMEDA AUC <0.7)

Exclusion criteria

  • Acute medical issues (e.g., uncontrolled hypertension)
  • Severe cognitive impairment (MMSE <24)
  • Exercise contraindications
  • Concurrent conflicting trials

Treatment and study plan

Gait Training

Other

Both groups: 12 weeks, 3 sessions/week × 60 min, supervised. Intervention Group (n=70): Progressive targeted ankle proprioceptive training

Primary outcomes

  1. Primary outcome

    Time frame: post-12 weeks, 6-month follow-up. Longitudinal subsample assessed from acute (<1 month) to chronic.

    Active Movement Extent Discrimination Apparatus for measuring propioceptive acuity

Secondary outcomes

  1. Secondary outcome

    Time frame: post-12 weeks, 6-month follow-up. Longitudinal subsample assessed from acute (<1 month) to chronic.

    Berg Balance Scale for assessment of static balance and fall risk.

Sponsors and collaborators

Lead sponsor

Iqra National University

Other

Registry information

Official study title

Targeted Ankle Proprioceptive Training Improves Balance, Gait, and Functional Mobility in Chronic Stroke Survivors: A Multicenter Randomized Controlled Trial With Longitudinal Follow Up

Important dates

Study start
2023
Primary completion
2024
Study completion
2025
First posted
Feb 19, 2026
Registry last updated
Feb 19, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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