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NCT Number: NCT06882369

TAP Block , Intrathecal Morphine Or Their Combination For Post Operative Analgesia Following TAH

This randomized controlled clinical trial designed to evaluate the efficacy of transversus abdominis plane (TAP) block, intrathecal morphine, or their combination in postoperative pain relief, as assessed by time to first analgesic request, pain scores, total postoperative analgesic consumption, time of ambulation, complications and hemodynamics following total abdominal hysterectomy.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Post-operative Pain Management

Age range

30 year–70 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 1

Primary location

Faculty of Medicine, Minia University

Minya, Minya Governorate, 61111, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female patients aged 30 to 70 years.
  • Elective total abdominal hysterectomy.
  • ASA physical status I or II.
  • Willingness to provide informed consent.

Exclusion criteria

  • Refusal of the block.
  • Allergy to study medications.
  • Preexisting coagulation disorders.
  • Local infection at the site of needle insertion.
  • Uncontrolled respiratory or cardiac disorders.
  • Impaired kidney or liver function.

Treatment and study plan

TAP Block

Procedure

The transabdominal plane (TAP) block is a regional anesthesia technique used for postoperative pain management in abdominal wall procedures, providing somatic analgesia to the anterior and lateral abdominal walls

Intrathecal morphine injection

Drug

Intrathecal injection of morphine plus 20 mg hyperbaric bupivacaine in spinal anesthesia

spinal anesthesia

Drug

intrathecal injection of bupivacaine

Primary outcomes

  1. Time to first analgesic request

    Time frame: 24 hours

    Time (in hours) until the patient demand additional analgesia.

Secondary outcomes

  1. Total analgesic consumption

    Time frame: 24 hours

    Cumulative postoperative analgesic consumption

  2. Time to ambulation

    Time frame: 24 hours

    Time (in hours) from arrival in the PACU until the patient was able to walk.

  3. complications

    Time frame: 24 hours

    Incidence of nausea, vomiting, pruritus, respiratory depression, hematoma, infection or hemodynamic instability

Sponsors and collaborators

Lead sponsor

Minia University

Other

Registry information

Official study title

Efficacy Of Transversus Abdominis Plane Block , Intrathecal Morphine Or Their Combination For Post Operative Analgesia Following Total Abdominal Hysterectomy.

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Mar 18, 2025
Registry last updated
Mar 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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