Take the Reins: The Effects of Nutrient Timing on Cancer-related Fatigue

Inclusion criteria

(Participants must…):

• Have a diagnosis of a hematologic neoplasm (e.g., leukemia, lymphoma, multiple myeloma);
• Be at least 2 months post-treatment with chemotherapy, radiation, targeted therapy, chimeric antigen receptor (CAR)-T cell therapy, stem cell transplant, or another therapy (maintenance therapies are okay; steady unchanged treatment for relapsed disease for >2 months and expected to stay on it until progression is okay);
• Have a baseline level of fatigue, as determined by at least one of the following:

• Reporting a score of 4 or higher in response to the question, "What was your worst fatigue in the last week, on a scale of 0-10, where 0 is no fatigue and 10 is the worst fatigue?"
• In the habit of taking daytime naps,
• Have fatigue that interferes with their ability to work, engage in social events, or is more than would be expected from physical exertion,
• Be able to speak and/or read and write in English or Spanish;
• Be at least 18 years old; and
• Be able to provide informed consent.

Exclusion criteria

(participants must not…)

• Be underweight, as defined as a body mass index <18.5 kg/m2;
• Already eat all their food within a window that is 10 h or shorter most (6/7) days of the week;
• Be employed in a job where they regularly work away from the home at night (e.g., night shift);
• Have surgery planned during the study duration;
• Have any contraindications to the proposed nutrition intervention as identified by their medical provider, their designee, or the study team (e.g., type 1 diabetes, risk for hypoglycemia, medication requirements, pregnancy, breastfeeding, recent history of an eating disorder);
• Be taking insulin; or
• Be on enteral or parenteral nutrition.