Taiwan Diabesity Study:Comparison With Mild Obese T2DM Patients Who Under Metabolic Surgery

This study will recruit 200 obese T2DM patients at MSGH, for a total of 1000 in Taiwan. The inclusion criteria are those with T2DM more than 6 months, under medical management in diabetes center, BMI over 25, age between 20 and 67 years. The goals of this study are to evaluate the nature course of the diabetes for 10 years. The primary outcomes for the treatment will be assessed every year after intervention and will be composite of CVD risk factor; specifically, the proportion of patients with HbA1c < 7%, LDL cholesterol < 100 mg/dl and systolic blood pressure < 140 mmHg.

Inclusion criteria

• Diabetic Mellitus Type 2 medically controlled at Diabetes Center for at least six months
• BMI over 25
• age between 20 and 67

Exclusion criteria

• Diagnosed with cancer within past five years
• HIV positive
• Active TB patients
• CV events in past six months
• serum cretinine over 2.0 mg/dl
• C-peptide bellow 1.0 ng/ml in past three months
• Diabetic retinopathy; vision bellow 0.1
• Cushing's syndrome
• History of organ transplant
• History of bariatric surgery
• History of alcohol or drug dependency in past five years
• Psychological problems likely to interfere with adherence to protocol