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OpenTrials
Completed

NCT Number: NCT03431688

Tailored Therapy for Clarithromycin-Resistant H. Pylori

Clarithromycin-resistant H. pylori is the main cause of H. pylori eradication failure. Tailored therapy on the basis of detection of a clarithromycin resistance mutation by PCR has been studied recently, however, there have been few studies comparing treatment regimen in patient with clarithromycin-resistant H. pylori. We used sequencing-based clarithromycin resistance mutation and aimed to compare PAM (proton pump inhibitor, amoxicilline, metronidazole) regimen and PBMT (proton pump inhibitor, bismuth, metronidazole, tetracyclin) regimen in patient with clarithromycin-resistant H. pylori.

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Key information

Conditions

Helicobacter Pylori Infection

Age range

19 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kangdong Sacred Heart Hospital

Seoul, 134-701, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • peptic ulcer disease
  • H. pylori gastritis
  • low grade MALT lymphoma

Exclusion criteria

  • history of gastric cancer surgery
  • severe comorbidity (ESRD, LC)
  • hypersensitivity to drug
  • pregnancy

Treatment and study plan

PAM

Drug

treatment with PPI, metonidazole, amoxicillin

PBMT

Drug

treatment with PPI, metonidazole, bismuth, tetracyclin

Primary outcomes

  1. H. pylori eradication rate

    Time frame: 14 days

    H. pylori eradication rate

Sponsors and collaborators

Lead sponsor

Kangdong Sacred Heart Hospital

Other

Registry information

Official study title

Efficacy Comparison of Metronidazole-based Triple and Bismuth-based Quadruple Therapy for Clarithromycin Resistant-Helicobacter Pylori Infection: Randomized Controlled Trial

Important dates

Study start
2018
Primary completion
2020
Study completion
2020
First posted
Feb 13, 2018
Registry last updated
Sep 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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