Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07533409

Tactile and Pain Sensory Thresholds and Hand Grip Strength

The aim of this study was to compare fingertip tactile sensation, hand and finger grip strength, and hand pain thresholds in children diagnosed with specific learning disorder with impairment in written expression and healthy controls.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Sensation Diminished, Pinprick Communication Disorders Learning Disabilities Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurodevelopmental Disorders Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Sensation Disorders Signs and Symptoms Somatosensory Disorders Specific Learning Disorder Specific Learning Disorder, With Impairment in Written Expression

Age range

6 year–12 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

for specific learning disorder with impairment in written expression:

  • Diagnosis of specific learning disorder with impairment in written expression according to the DSM-5 diagnostic criteria
  • Age between 6 and 12 years
  • Clinically normal intellectual functioning
  • Voluntary agreement to participate in the study
  • Absence of any systemic disease
  • Right-hand dominance

Inclusion criteria

for control:

  • Age between 6 and 12 years
  • Clinically normal intellectual functioning
  • Willingness to participate in the study on a voluntary basis
  • Absence of any systemic disease
  • Right-hand dominance

Exclusion criteria

for specific learning disorder with impairment in written expression:

  • Presence of verbal or visual communication problems
  • History of perinatal complications or physical head trauma
  • Presence of psychiatric disorders other than specific learning disorder according to the DSM-5 diagnostic criteria
  • History of known chronic physical or neurological disease (such as cerebral palsy, diabetes, epilepsy, autoimmune disease, liver failure, or kidney failure)
  • Presence of substance or alcohol use disorder
  • Diagnosis of a genetic disorder
  • Previous surgery involving the hand region
  • Presence of infection and/or sensory deficit in the hand region

Exclusion criteria

for control:

  • Presence of any psychiatric disorder according to the DSM-5 diagnostic criteria
  • Presence of verbal or visual communication problems
  • History of perinatal complications or physical head trauma
  • History of known chronic physical or neurological disease (such as cerebral palsy, diabetes, epilepsy, autoimmune disease, liver failure, or kidney failure)
  • Presence of substance or alcohol use disorder
  • Diagnosis of a genetic disorder
  • Previous surgery involving the hand region
  • Presence of infection and/or sensory deficit in the hand region

Treatment and study plan

Treatment outcome

Other

The participants' fingertip light touch and pain sensory thresholds, as well as hand and fingertip pinch strength, will be evaluated.

Primary outcomes

  1. Fingertip light touch

    Time frame: Baseline

    The participants' light touch sensory thresholds will be assessed using Semmes-Weinstein monofilaments, which consist of calibrated synthetic monofilaments that differ in thickness and the amount of pressure applied. Measurements will be taken from the midpoint of the distal phalanx on the palmar surface of the first, second, and third fingers of the right hand. The test will be performed with the participants' eyes closed; starting with the smallest monofilament, contact will be applied to the test area and progressively larger monofilaments will be used. The test will be terminated when the participant first perceives the touch, and the corresponding value will be recorded.

  2. Hand grip strength

    Time frame: Baseline

    Hand grip strength will be assessed using a Jamar dynamometer (Patterson Medical, Green Bay, WI, USA). During the assessment, the participant will be seated with the shoulders adducted and in neutral rotation, the elbow flexed at 90°, the forearm in a neutral position, and the wrist between 0° and 30° of dorsiflexion. The evaluator will gently support the base of the dynamometer, place it in the participant's hand, and instruct the participant to squeeze as hard as possible. Three measurements of maximum voluntary contraction will be obtained for the right hand, and the highest value will be recorded in kilograms.

  3. Finger pinch strength

    Time frame: Baseline

    The pinch strength between the thumb and index finger of the participants' right hand will be assessed using a Jamar pinch gauge. During the assessment, the shoulder will be in adduction and neutral rotation, the elbow flexed at 90°, the forearm in mid-rotation, and the wrist in a neutral position. The participant will be instructed to squeeze the pinch gauge between the thumb and index finger as hard as possible. Three measurements of maximum voluntary contraction will be obtained for the right hand, and the highest value will be recorded in kilograms.

  4. Pressure pain threshold

    Time frame: Baseline

    The pressure pain threshold will be used to assess the patients' pain perception threshold. Pressure pain threshold will be measured using a manual pressure algometer (Baseline Dolorimeter®). The patients' pain perception thresholds will be measured at the right lateral epicondyle and at the midpoint of the web space between the first and second fingers. During the measurement, the algometer's flat circular probe with a surface area of 1.52 cm² will be placed on the relevant site, and pressure will be increased at a rate of 1 kg/second. The patients will be instructed to indicate the onset of pain by saying "stop" or by raising their hand when they begin to feel slight discomfort. For each reference site, the value will be calculated as the arithmetic mean of two measurements taken 30 seconds apart.

Study contacts

Contact information is provided by the study sponsor or research team.

Alper Mengi, MD

CONTACT

[email protected]

+90 537 651 03 85

Sponsors and collaborators

Lead sponsor

Sultan 1. Murat State Hospital

Other Gov

Registry information

Official study title

Comparison of Tactile and Pain Sensory Thresholds and Hand Grip Strength in Children Diagnosed With Specific Learning Disorder With Impairment in Written Expression and Healthy Controls

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 16, 2026
Registry last updated
Apr 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.