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NCT Number: NCT06029062

tACS for Sensory Motor Recovery After Stroke

The overall goal is to investigate the effectiveness of a novel intervention - transcranial alternating current stimulation (tACS) for motor recovery in stroke survivors.

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Key information

Conditions

Motor Recovery

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion/exclusion criteria for stroke subjects

Inclusion criteria

  • Age between 18~75 years old
  • ≥ 6 months post stroke, medically stable;
  • Unilateral, single stroke (no restriction on type (ischemic or hemorrhagic) or volume (large or small) of stroke);
  • Visible finger flexor activation/movement
  • The ability to give consent

Exclusion criteria

  • Patients with visual deficit/neglect; hearing or cognitive impairment;
  • Patients that are currently adjusting tone alternating medications (e.g., baclofen), or
  • Patients received botulinum toxin injection to the arm/fingers <4 months, or phenol injections <2 years;
  • Patients with pacemaker, metal implants or supplemental oxygen;
  • Patients who have musculoskeletal disorders, including pain in the affected side
  • Women who are pregnant.

Treatment and study plan

tACS Sham

Device

Sham tACS will applied to the brain through the scalp for 20 minutes.

tACS 10Hz

Device

10Hz tACS will applied to the brain through the scalp for 20 minutes.

tACS 20Hz

Device

20Hz tACS will applied to the brain through the scalp for 20 minutes.

Primary outcomes

  1. Block and Box Test (BBT) of Motor functional test

    Time frame: Change of BBT performance 5 minutes before and 5 minutes after the tACS intervention will be measured.

    The Box and Block Test (BBT) measures unilateral gross manual dexterity. It is a quick and simple test used with a wide range of populations, including clients with stroke.

  2. EEG alpha band and Beta band

    Time frame: Change of EEG alpha band and Beta band 5 minutes before and 5 minutes after the tACS intervention will be measured.

    Electroencephalography (EEG) is valuable to infer and evaluate the neural interaction. Components of the alpha and beta frequency bands like the sensorimotor rhythm originated from the primary motor cortex and related brain areas reflect human movement. The power of 8-13 Hz alpha and 14-30 Hz beta frequency bands will be used for the classification.

Study contacts

Contact information is provided by the study sponsor or research team.

Sheng Li, MD, Ph.D

CONTACT

[email protected]

(713) 797-7125

Shengai Li, MS

CONTACT

[email protected]

713-797-7561

Sponsors and collaborators

Lead sponsor

The University of Texas Health Science Center, Houston

Other

Registry information

Official study title

tACS Brain Neuromodulation for Sensory and Motor Recovery After Neurological Impairments

Important dates

Study start
2025
Primary completion
2027
Study completion
2028
First posted
Sep 8, 2023
Registry last updated
Jun 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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