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NCT Number: NCT07103356

Table-Top Water Pitcher to Reduce Arsenic Exposure Among Well Users in New Hampshire

The goals of this clinical trial are to:

1. gather preliminary data on the effectiveness of a table-top water pitcher filtration system in reducing arsenic exposure among individuals using private wells with elevated (>5 μg/L) arsenic concentrations, and 2. identify the factors influencing implementation of the filter intervention (uptake and sustainability) and barriers and facilitators to its use.

The main questions it aims to answer are:

Do water and urinary arsenic concentrations change from baseline to Week 4 of the water pitcher intervention?

Are changes in arsenic concentrations maintained during the eight-week sustainability period?

* Which factors facilitate or impede uptake, use, and sustainability of the intervention? * Are household income and/or home ownership associated with sustained filter use?

Participants will:

* Receive a free 12-cup water filter pitcher and cartridge replacements * Use the pitcher filtration system, including replacement of filter cartridges, per manufacturer recommendations * Collect and mail water and urine samples at baseline, 4 weeks, and 12 weeks * Complete online questionnaires at baseline, 4 weeks, and 12 weeks

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Key information

Conditions

Arsenic Poisoning Chemically-Induced Disorders Environmental Exposure Heavy Metal Poisoning, Nervous System Infections Nervous System Diseases Neurotoxicity Syndromes Poisoning Water-Related Diseases Waterborne Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Geisel School of Medicine at Dartmouth

Lebanon, New Hampshire, 03756, United States

Location status: Recruiting

Location contact

Caitlin G Howe, PhD

CONTACT

[email protected]

603-646-5419

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18 years or older
  • NH resident living in Merrimack or Belknap county
  • Use a private water system as primary drinking water source
  • Water arsenic >5 micrograms/L upon testing
  • Confirm would be primary person in home maintaining the provided pitcher filter

Exclusion criteria

  • Use or plan to use a mitigation strategy to reduce exposure to arsenic-contaminated drinking water in the next 12 weeks

Treatment and study plan

Water Pitcher Filtration System

Behavioral

Table-top water pitcher filtration system

Primary outcomes

  1. Water arsenic concentrations

    Time frame: 4 weeks

    Changes in water arsenic concentrations from baseline to week 4

  2. Urinary arsenic concentrations

    Time frame: 4 weeks

    Changes in urinary arsenic concentrations from baseline to week 4

  3. Reach

    Time frame: 4 weeks

    Number of participants who receive the water pitcher filtration system among all eligible individuals and demographics

  4. Adoption

    Time frame: 4 weeks

    Number of participants using the filtration system after receiving it; number of participants who intend to use the system after the study period ends; and demographics of participants who used the filtration system during the study period or intend to use it after the study period ends

  5. Implementation

    Time frame: 4 weeks

    % of participants who adhere to the intervention during the intervention period (Fidelity), including using the pitcher filtration system for all drinking and cooking water and changing filter cartridges as recommended (measured by questionnaire: at home, did you use the pitcher filtration system for all of your drinking water, more than half of your drinking water, half of your drinking water, less than half of your drinking water, or none of your drinking water AND did you use did you use the pitcher filtration system for all of your cooking water, more than half of your cooking water, half of your cooking water, less than half of your cooking water, or none of your cooking water)

  6. Maintenance

    Time frame: 8 weeks

    % of participants who continue to use the pitcher filtration system during the 8-week sustainability period when replacement filter cartridges are no longer provided (measured by questionnaire: at home, did you use the pitcher filtration system for all of your drinking water, more than half of your drinking water, half of your drinking water, less than half of your drinking water, or none of your drinking water AND did you use did you use the pitcher filtration system for all of your cooking water, more than half of your cooking water, half of your cooking water, less than half of your cooking water, or none of your cooking water)

Study contacts

Contact information is provided by the study sponsor or research team.

Caitlin Howe, PhD

CONTACT

[email protected]

603-646-5419

Sponsors and collaborators

Lead sponsor

Trustees of Dartmouth College

Other

Registry information

Official study title

Developing a Hybrid Type 1 Effectiveness-Implementation Randomized Controlled Trial to Test a Table-Top Water Pitcher to Reduce Arsenic Exposure in Northern New England

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Aug 5, 2025
Registry last updated
Mar 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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